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Table of Contents ( Mark One ) UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington D.C. 20549 FORM 10 - K ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31 , 2020 OR TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from Commission file number : 001-36294 to Title of Each Class Ordinary shares , par value € 0.05 per share uniQure uniQure N.V. ( Exact name of Registrant as specified in its charter ) The Netherlands ( Jurisdiction of incorporation or organization ) Paasheuvelweg 25a , 1105 BP Amsterdam , The Netherlands ( Address of principal executive offices ) ( Zip Code ) + 31-20-240-6000 ( Registrant's telephone number , including area code ) Securities registered pursuant to Section 12 ( b ) of the Act : Trading Symbol ( s ) Name of Each Exchange on Which Registered QURE The Nasdaq Stock Market LLC ( The Nasdaq Global Select Market ) Securities registered under Section 12 ( g ) of the Act : None Indicate by check mark if the registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . Yes No Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15 ( d ) of the Act . Yes No Indicate by check mark whether the registrant ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding months ( or for such shorter period that the registrant was required to such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days . Yes No Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S - T ( § 232.405 of this chapter ) during the preceding 12 months ( or for such shorter period that the registrant was required to submit such files ) . Yes No Indicate by check mark whether the registrant is a large accelerated filer , an accelerated filer , a non - accelerated filer , a smaller reporting company , or an emerging growth company . See the definitions of " large accelerated filer " , " accelerated filer " , " smaller reporting company " and " emerging growth company " in Rule 12b - 2 of the Exchange Act . Large accelerated filer > Accelerated filer Non - accelerated filer Smaller reporting company Emerging growth company If an emerging growth company , indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13 ( a ) of the Exchange Act . Indicate by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness of its internal control over financial reporting under Section 404 ( b ) of the Sarbanes - Oxley Act ( 15 U.S.C. 7262 ( b ) ) by the registered public accounting firm that prepared or issued its audit report . Indicate by check mark whether the registrant is a shell company ( as defined in Rule 12b - 2 of the Act . ) Yes No The aggregate market value of the voting and non - voting ordinary shares held by non - affiliates of the registrant as of June 30 , 2020 was $ 2,002.7 million , based on the closing price reported as of June 30 , 2020 on the NASDAQ Global Select Market . As of February 25 , 2021 , the registrant had 44,993,987 ordinary shares , par value € 0.05 , outstanding . The documents incorporated by reference are as follows : Portions of the registrant's definitive Proxy Statement for its 2021 Annual Meeting of Shareholders to be filed with the Securities and Exchange Commission no later than April 30 , 2021 and to be delivered to shareholders in connection with the 2021 Annual Meeting of Shareholders , are herein incorporated by reference in Part III of this Annual Report on Form 10 - K .