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R REPLIGEN INSPIRING ADVANCES IN BIOPROCESSING Repligen Reports Second Quarter 2021 Financial Results and Updates Full Year 2021 Financial Guidance Repligen Corporation 41 Seyon Street ● Exhibit 99.1 Financial Highlights for the Second Quarter 2021 Building # 1 , Suite 100 Waltham , Massachusetts 02453 Reported revenue was $ 163.0 million for the quarter , representing year - over - year growth of 86 % and organic growth of 69 % Revenue guidance raised to $ 625- $ 645 million for full year 2021 Acquisition of hollow fiber innovator Polymem S.A. completed July 1 , 2021 WALTHAM , Mass . - July 27 , 2021 - Repligen Corporation ( NASDAQ : RGEN ) , a life sciences company focused on bioprocessing technology leadership , today reported financial results for its second quarter of 2021. Provided in this press release are financial highlights for the three- and six - month periods ended June 30 , 2021 , updates to our financial guidance for the fiscal year 2021 and access information for today's webcast and conference call . Tony J. Hunt , President and Chief Executive Officer said , “ We delivered an outstanding second quarter and first half of the year for the Company , with strength across the board in all our franchises . During the second quarter , our filtration revenue more than doubled year - over - year . Orders related to COVID programs now extend well into 2022 , while our base business revenues continued to grow at greater than 30 % for the second quarter in a row . We finished the quarter by announcing the acquisition of Polymem S.A. , an expert and innovator in hollow fiber technology , immediately expanding our capacity and strengthening our core capabilities . Based on this continued momentum , we are updating our 2021 financial guidance to reflect revenue growth in the range of 71 % -76 % and healthy margin expansion . " Revenue increased by $ 75.5 million in the second quarter , or 86 % year - over - year , as reported and 69 % organically , to $ 163.0 million Our base business accounted for 66 % of revenue and grew 35 % year - over - year COVID - related sales accounted for 27 % of revenue Revenue from acquisitions made in 2020 accounted for 7 % of revenue GAAP gross margin and adjusted gross margin ( non - GAAP ) each increased to 62.0 % GAAP operating margin was 29.6 % , an increase of 730 bps Adjusted ( non - GAAP ) operating margin was 34.7 % , an increase of 550 bps GAAP fully diluted EPS increased to $ 0.64 compared to $ 0.30 for the second quarter of 2020 Adjusted fully diluted EPS ( non - GAAP ) increased to $ 0.79 compared to $ 0.42 for the second quarter of 2020 1