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Rapid Micro Biosystems 44th Annual J.P. Morgan Healthcare Conference Rob Spignesi, President & CEO January 15, 2026 R A P I D M I C R O B I O S Y S T E M S N A S D A Q : R P I D © 2025, Rapid Micro Biosystems, Inc. | RAPID MICRO BIOSYSTEMS® and GROWTH DIRECT® are registered trademarks of Rapid Micro Biosystems, Inc., and the company logo is a trademark of Rapid Micro Biosystems, Inc.
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Rapid Micro Biosystems Disclaimers 2 This presentation has been prepared by Rapid Micro Biosystems, Inc. (the “Company”) solely for informational purposes. This presentation includes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. All statements contained in this presentation that do not relate to matters of historical fact should be considered forward-looking statements, including, but not limited to, preliminary fourth quarter and full year 2025 results; expected placements of Growth Direct systems, anticipated timing of such placements and the impact on the Company’s revenue; expectations and goals with respect to continued improvement in gross margins and cash management; and the Company’s Distribution and Collaboration Agreement and the terms thereof, including future collaboration opportunities between the parties; the benefits and features of the Company's products and technology; the Company's goal to achieve cashflow breakeven; the Company's revenue and gross margin expectations, including the drivers thereof; and the Company's efforts to drive sustainable, long-term growth and shareholder value. In some cases, you can identify forward-looking statements by terminology such as “outlook,” “aim,” “anticipate,” “assume,” “believe,” “contemplate,” “continue,” “could,” “due,” “estimate,” “expect,” “goal,” “intend,” “may,” “objective,” “plan,” “predict,” “potential,” “positioned,” “seek,” “should,” “target,” “will,” “would” and other similar expressions that are predictions of or indicate future events and future trends, or the negative of these terms or other comparable terminology, although not all forward-looking statements contain these words. Forward-looking statements involve known and unknown risks, uncertainties and assumptions which may cause actual results to differ materially from any results expressed or implied by any forward-looking statement, including, but not limited to the Company’s significant losses since inception; the Company’s ability to meet its publicly announced guidance and other expectations about its business and operations; the effectiveness of the Company’s sales and marketing efforts; the Company’s ability to sell and place its products with customers; the Company’s ability to develop new products and adapt to technological change; the Company’s ability to establish and maintain its position as a leading provider of automated microbial quality control testing; competition within the Company’s industry; the Company’s ability to maintain its manufacturing operations; the Company’s efforts to improve gross margins for its products; the Company’s ability to maintain and grow its relationships with its collaborators, including MilliporeSigma; the Company’s ability to manage its collaboration with MilliporeSigma and to realize the intended benefits of the distribution and collaboration agreement; the impact of the terms of the distribution and collaboration agreement on the Company’s business and results of operations; the Company’s ability to negotiate and enter into future collaboration opportunities with MilliporeSigma, and to realize the intended benefits therefrom; the impact of the Company's existing and any future indebtedness on its ability to operate its business; the Company’s ability to access any future tranches under its debt facility and to comply with all of its obligations thereunder; risks related to third-parties; the Company’s ability to retain key management and other employees; risks related to regulatory and intellectual property matters; risks related to supply chain disruptions and the impact of inflation; the impact of macroeconomic volatility on the Company’s business and operations; and the other important factors outlined under the caption “Risk Factors” in the Company’s most recent Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (“SEC”) on November 7, 2025, as such factors may be updated from time to time in its other filings with the SEC, which are available on the SEC's website at www.sec.gov and the Investor Relations page of its website at investors.rapidmicrobio.com. Although the Company believes that the expectations reflected in its forward-looking statements are reasonable, it cannot guarantee future results. The Company has no obligation, and does not undertake any obligation, to update or revise any forward-looking statement made in this presentation to reflect changes since the date of this presentation, except as may be required by law. The Company has presented preliminary financial results for the fourth fiscal quarter and full year 2025 that have not been audited and are subject to adjustment based on the Company’s completion of year-end financial close processes. © 2025, Rapid Micro Biosystems, Inc. | RAPID MICRO BIOSYSTEMS® and GROWTH DIRECT® are registered trademarks of Rapid Micro Biosystems, Inc., and the company logo is a trademark of Rapid Micro Biosystems, Inc.
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Rapid Micro Biosystems C Our vision We are transforming a critical, regulated part of the global pharmaceutical manufacturing process, bringing microbial quality control into the 21st century. The new standard in microbial quality control Rapid Micro Biosystems 3© 2025, Rapid Micro Biosystems, Inc. | RAPID MICRO BIOSYSTEMS® and GROWTH DIRECT® are registered trademarks of Rapid Micro Biosystems, Inc., and the company logo is a trademark of Rapid Micro Biosystems, Inc.
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Rapid Micro Biosystems The standard in automating microbial quality control 4 20% Year / Year Growth $33.6M Total Revenue 2 0 2 5 R E V E N U E1 G L O B A L S Y S T E M S1 C U S T O M E R S $17.8M Recurring Revenue 155 Cumulative Validations 190 Cumulative Placements ~20 Countries 86% Approved CAR-T Manufacturers 75% Top 20 Global Pharma2 Rapid Micro Biosystems 1 Preliminary and unaudited for the year ended Dec. 31, 2025 2 By revenue © 2025, Rapid Micro Biosystems, Inc. | RAPID MICRO BIOSYSTEMS® and GROWTH DIRECT® are registered trademarks of Rapid Micro Biosystems, Inc., and the company logo is a trademark of Rapid Micro Biosystems, Inc.
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Rapid Micro Biosystems Record quarterly revenue; exceeded full year guidance following guidance increase (FY’25); 13th quarter of meeting / exceeding revenue guidance. Strong recurring revenue - double digit growth in FY’25. Record multi-system Growth Direct system order, as previously announced, from an existing Top 20 global biopharma customer to automate global manufacturing network. Meaningful gross margin improvement (FY’25) & strengthened balance sheet with $45m term loan facility. Strategic partnership with MilliporeSigma to drive growth, margin expansion and innovation. 2025 revenue guidance exceeded with record fourth quarter 5 R E S U LT S Q 4 2 0 2 51 F Y 2 0 2 51 Total Revenue $11.3M 37% growth $33.6M 20% growth Recurring Revenue $4.6M 41% of total $17.8M 53% of total Systems Placed 16 28 Systems Validated 3 18 © 2025, Rapid Micro Biosystems, Inc. | RAPID MICRO BIOSYSTEMS® and GROWTH DIRECT® are registered trademarks of Rapid Micro Biosystems, Inc., and the company logo is a trademark of Rapid Micro Biosystems, Inc. S E L E C T H I G H L I G H T S 1 Preliminary and unaudited for the year ended Dec 31, 2025
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Rapid Micro Biosystems Scientific and technology innovation Growing demand for more complex therapies Faster & leaner manufacturing Data integrity & security focus Regulatory scrutiny+ F A C T O R S D R I V I N G C H A N G E Discovery & research QC & ANALYSIS Bioprocessing & manufacturing T O D A Y T O D A Y T O D A Y Flexible single use technologiesHigh-throughput R&D automation MQC has not kept up with pharma industry innovation + + + 6Rapid Micro Biosystems © 2025, Rapid Micro Biosystems, Inc. | RAPID MICRO BIOSYSTEMS® and GROWTH DIRECT® are registered trademarks of Rapid Micro Biosystems, Inc., and the company logo is a trademark of Rapid Micro Biosystems, Inc.
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Rapid Micro Biosystems Insecure and lacking data integrity High volume testing and mandated by regulators Manual, paper-based and slow Subjective and prone to human error 7 Challenges in a traditional microbial quality control (MQC) lab © 2025, Rapid Micro Biosystems, Inc. | RAPID MICRO BIOSYSTEMS® and GROWTH DIRECT® are registered trademarks of Rapid Micro Biosystems, Inc., and the company logo is a trademark of Rapid Micro Biosystems, Inc.
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Rapid Micro Biosystems THE GROWTH DIRECT® (GD) PLATFORM The only fully automated, high-throughput and secure MQC solution… Proprietary Consumables Data & Software Global Validation & Support Services …delivering a compelling value proposition Data Integrity Supports global quality regulatory compliance and improved data handling and management Operational Efficiency Enables faster decision making by accelerating time to results by 50% or faster compared to the traditional method Insight & Accuracy Eliminate human quality control errors, preventing costly recalls and regulatory interventions 8 Introducing the Growth Direct® platform © 2025, Rapid Micro Biosystems, Inc. | RAPID MICRO BIOSYSTEMS® and GROWTH DIRECT® are registered trademarks of Rapid Micro Biosystems, Inc., and the company logo is a trademark of Rapid Micro Biosystems, Inc.
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Rapid Micro Biosystems P U L L Q C T E S T FO R M 1. FIL L O U T A S S A Y IN FO 2. P R E P A R E S A MP L E S 3. L O A D IN C U B A T O R 4. P U L L S A MP L E S 5. P E R FO R M C O U N T S 6. R E C O R D C O U N T S 7. R E T U R N S A MP L E S 8. S H IFT S A MP L E S 9. P U L L S A MP L E S 10. P E R FO R M C O U N T S 11. D IS C A R D 15. KEY IN T O L IMS 14. P E R FO R M D U A L-R E A D 12. R E C O R D C O U N T S 13. R E S U LT S Prepare sample & automated loading 1 Automated incubation and analysis & Data handling 2 Results Manual & subject to error 15 steps 5-14 days to result / test Unsecured Automated & accurate 2 steps Results in half the time Full data integrity 9 Growth Direct® transforms and modernizes MQC M A N U A L W O R K F L O W G R O W T H D I R E C T® A U T O M A T E D W O R K F L O W Rapid Micro Biosystems © 2025, Rapid Micro Biosystems, Inc. | RAPID MICRO BIOSYSTEMS® and GROWTH DIRECT® are registered trademarks of Rapid Micro Biosystems, Inc., and the company logo is a trademark of Rapid Micro Biosystems, Inc.
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Rapid Micro Biosystems The Growth Direct® System brings MQC into the 21st Century Discovery & research QC & ANALYSIS Bioprocessing & manufacturing T O D A YT O D A Y T O D A Y 10 Scientific and technology innovation Growing demand for more complex therapies Faster & leaner manufacturing Data integrity & security focus Regulatory scrutiny+ F A C T O R S D R I V I N G C H A N G E + + + © 2025, Rapid Micro Biosystems, Inc. | RAPID MICRO BIOSYSTEMS® and GROWTH DIRECT® are registered trademarks of Rapid Micro Biosystems, Inc., and the company logo is a trademark of Rapid Micro Biosystems, Inc. Flexible single use technologiesHigh-throughput R&D automation
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Rapid Micro Biosystems Market forces pushing pharma industry to automation 11 Sources: FDA, EvaluatePharma, Alliance for Regen. Medicine © 2025, Rapid Micro Biosystems, Inc. | RAPID MICRO BIOSYSTEMS® and GROWTH DIRECT® are registered trademarks of Rapid Micro Biosystems, Inc., and the company logo is a trademark of Rapid Micro Biosystems, Inc. Regulatory Pressure Increasing regulatory scrutiny and enforcement around data integrity and quality Industry Change Growth in complex biologics and cell & gene therapies which require faster, more accurate, higher throughput testing capabilities Large and Growing Market $5B annual recurring revenue + $5B global system opportunity Expanding Manufacturing Capacity, Especially U.S. Reshoring Increasing investments in new manufacturing capacity create significant opportunity for automation
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Rapid Micro Biosystems Growth strategy focused on land and expand augmented by innovation 12 P U R S U E AD J A C E N T M AR K E T S D R I V E E N T E R P R I S E D E P L O Y M E N T S E X P AN D I N T O N E W G E O G R AP H I E S L AU N C H N E W P R O D U C T S AN D S E R V I C E S G R O W N E W C U S T O M E R AD O P T I O N BIO PHARMA (incl. cell & gene) CDMO STERILE INJECTABLE, VACCINE, & OTHER LAND AND EXPAND STRATEGY Sample automation Additional test types (e.g. sterility) Data services and SaaS Automated microbial ID Core Growth Direct Capabilities EM + W/BB + Sterility + EM + W/BB + Sterility + EM + W/BB + Sterility + Site 1 Site 2 Site 3+ © 2025, Rapid Micro Biosystems, Inc. | RAPID MICRO BIOSYSTEMS® and GROWTH DIRECT® are registered trademarks of Rapid Micro Biosystems, Inc., and the company logo is a trademark of Rapid Micro Biosystems, Inc.
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Rapid Micro Biosystems 13 C U S T O M E R S E G M E N T S W I T H E S T A B L I S H E D U S E G L O B A L S I T E S W I T H G R O W T H D I R E C T S Y S T E M S of approved CAR-T manufacturers have GD system placed 86% cumulative systems validated 155 cumulative consumables sold ~9M customer manufacturing sites 100+ cumulative systems placed 190 of top 20 global pharma are customers 75% G R O W T H D I R E C T AP P L I C AT I ON S Environmental Monitoring Water Testing Bioburden Testing Rapid Sterility Testing Rapid Micro Biosystems Biologics Small Molecules CDMO Personal Care Products Cell & Gene Therapy / CAR-T Customer base includes 75% of the top 20 global pharma companies1 with significant growth potential © 2025, Rapid Micro Biosystems, Inc. | RAPID MICRO BIOSYSTEMS® and GROWTH DIRECT® are registered trademarks of Rapid Micro Biosystems, Inc., and the company logo is a trademark of Rapid Micro Biosystems, Inc. 1 By revenue
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Rapid Micro Biosystems Annual 2-day event brings together industry thought-leaders, customers and prospective customers Largest event in seven-year history with over 25 companies participating and approximately 100 attendees from the U.S., Europe and Asia On-site tours and hands-on demonstrations First GD Day to include colleagues from Merck MilliporeSigma and several of their prospective customers 7th Annual Growth Direct Day – Driving Progress Together 14© 2025, Rapid Micro Biosystems, Inc. | RAPID MICRO BIOSYSTEMS® and GROWTH DIRECT® are registered trademarks of Rapid Micro Biosystems, Inc., and the company logo is a trademark of Rapid Micro Biosystems, Inc.
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Rapid Micro Biosystems 2022 2023 2024 2025 $17.1M $28.1M $22.5M ~$33.6M Strong and consistent revenue growth and margin improvement 15 +30% R E V E N U E G R O S S M A R G I N 2022 2023 2024 2025 Recurring Non-recurring ~60 percentage point improvement © 2025, Rapid Micro Biosystems, Inc. | RAPID MICRO BIOSYSTEMS® and GROWTH DIRECT® are registered trademarks of Rapid Micro Biosystems, Inc., and the company logo is a trademark of Rapid Micro Biosystems, Inc. 1 1 1 Preliminary and unaudited for the year ended Dec 31, 2025 Revenue Growth Drivers • New customer wins • Global deployments at existing customers • Merck MilliporeSigma partnership (distribution) • New products and services • Strong consumable and service growth Gross Margin Expansion Drivers • Reduced product costs • Improving manufacturing efficiency • Merck MilliporeSigma partnership (supply) • Increasing service productivity • Increasing volume
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Rapid Micro Biosystems A focused, scalable growth strategy built to deliver sustainable, long- term shareholder value Strategically well positioned for growth and margin expansion in 2026 and beyond 16© 2025, Rapid Micro Biosystems, Inc. | RAPID MICRO BIOSYSTEMS® and GROWTH DIRECT® are registered trademarks of Rapid Micro Biosystems, Inc., and the company logo is a trademark of Rapid Micro Biosystems, Inc. • Market leading product with strong growth and global adoption by top tier customer base • Commercial momentum driven by multi-system orders and market tailwinds • Strong and growing recurring revenue drive by consumables and services • Significant margin expansion achieved with continued expansion in 2026 and beyond • MilliporeSigma partnership set to meaningfully impact 2026 commercially • Strengthened balance sheet and financially healthy
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Rapid Micro Biosystems 17 Growth Direct® is the industry-leading platform Chosen by 75% of the top 20 global pharma companies1 with significant commercial runway Operating behind strong barriers to entry First mover advantage, little competition & robust patent portfolio Enabling advanced pharmaceutical manufacturing Growth Direct systems placed with 86% of approved CAR-T manufacturers An expanding $10B+ market Dominated by manual, legacy processes that face increasing FDA scrutiny Attractive, high-growth business model Driving high-yield recurring revenue Rapid Micro Biosystems Creating the future of rapid, secure MQC automation to drive sustainable, long-term growth and shareholder value 1 By revenue © 2025, Rapid Micro Biosystems, Inc. | RAPID MICRO BIOSYSTEMS® and GROWTH DIRECT® are registered trademarks of Rapid Micro Biosystems, Inc., and the company logo is a trademark of Rapid Micro Biosystems, Inc. 17
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Rapid Micro Biosystems Thank you © 2025, Rapid Micro Biosystems, Inc. | RAPID MICRO BIOSYSTEMS® and GROWTH DIRECT® are registered trademarks of Rapid Micro Biosystems, Inc., and the company logo is a trademark of Rapid Micro Biosystems, Inc.