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( Mark One ) þ UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , D.C. 20549 FORM 10 - K ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( D ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended June 30 , 2021 TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( D ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Transition Period from to 27-3440894 ( I.R.S. Employer Identification No. ) Nevada Commission File Number 000-54495 REZOLUTE , INC . ( Exact Name of Company as Specified in its Charter ) ( State or other jurisdiction of incorporation or organization ) 201 Redwood Shores Parkway , Suite 315 Redwood City , California ( Address of principal executive offices ) Registrant's telephone number , including area code : Securities registered pursuant to Section 12 ( b ) of the Act : 94065 ( Zip Code ) ( 650 ) 206-4507 Title of each class Trading Symbol ( s ) . Common Stock , par value $ 0.001 RZLT Name of each exchange on which registered Nasdaq Capital Market Securities registered pursuant to Section 12 ( g ) of the Act : None Indicate by check mark if the registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . YES ¨ NO þ Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15 ( d ) of the Act . YES þ NO¨ Indicate by check mark whether the Registrant ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the Company was required to file such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days . YES þ NO¨ Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S - T ( §232.405 of this chapter ) during the preceding 12 months ( or for such shorter period that the registrant was required to submit such files ) . YES þ NO¨ Indicate by check mark whether the registrant is a large accelerated filer , an accelerated filer , a non - accelerated filer , a smaller reporting company , and an emerging growth company . See the definitions of “ large accelerated filer ” , “ accelerated filer " , " smaller reporting company ” , and “ emerging growth company ” in Rule 12b - 2 of the Exchange Act . Large accelerated filer · Non - accelerated filer þ Accelerated filer Smaller reporting company þ Emerging growth company¨ If an emerging growth company , indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13 ( a ) of the Exchange Act . Indicate by check mark whether the registrant is a shell company ( as defined in Rule 12b - 2 of the Exchange Act ) . YES NO þ As of December 31 , 2020 , the last business day of the second fiscal quarter , the aggregate market value of the Registrant's voting stock held by non - affiliates , was approximately $ 75,933,018 , based on the last reported sales price of $ 11.99 as quoted on the Nasdaq Capital Market on such date .