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SAb BIOTHERAPEUTICS Personal Impact + Global Influence Exhibit 99.1 2100 EAST 54TH STREET NORTH SIOUX FALLS , SD 57104 SAB Biotherapeutics Reports Third Quarter 2021 Financial Results and Provides Company Update Advanced SAB - 185 to Phase 3 in NIH - Sponsored ACTIV - 2 Trial for treatment of COVID - 19 following positive DSMB recommendation at interim analysis Awarded additional $ 60.5 million from DoD in expanded scope for advancement of SAB - 185 Strengthened leadership team through appointment of Russell Beyer as Chief Financial Officer Sioux Falls , S.D. , November 22 , 2021 – SAB Biotherapeutics ( Nasdaq : SABS ) , ( SAB ) , a clinical - stage biopharmaceutical company with a novel immunotherapy platform that produces specifically targeted , high - potency , fully - human polyclonal antibodies without the need for human donors , today reported financial results for the third quarter ended September 30 , 2021 and provided a company update . " We entered the next stage of our growth with our recent debut as a public company , highlighted by the completion of our business combination with Big Cypress Acquisition Corp. in October , ” said Eddie J. Sullivan , PhD , co - Founder , President , and Chief Executive Officer of SAB Biotherapeutics . “ Our pipeline of potent and scalable human polyclonal antibodies leveraging our novel DiversitAb ™ platform continues to advance , and our clinical programs for SAB - 185 and SAB - 176 show strong therapeutic potential as they progress through clinical trials . We have built a strong team with exceptional experience and knowledge , enabling us to drive forward the development of highly - efficacious human polyclonal therapies with the potential to address the emergence , mutation , and diversity of modern health challenges . " Recent Developments and Upcoming Milestones Pipeline Updates : • Infectious Disease Pipeline : О SAB - 185 , a polyclonal antibody therapeutic candidate for the treatment of COVID - 19 is currently being evaluated in the ongoing Phase 3 ACTIV - 2 trial in collaboration with the US National Institutes of Health ( NIH ) for the treatment of non- hospitalized patients with mild to moderate COVID - 19 - In September , announced that an independent Data Safety Monitoring Board ( DSMB ) recommended advancement to Phase 3 following a prespecified interim analysis data review of the safety and efficacy of SAB - 185 in the Phase 2 portion of the ACTIV - 2 trial Awarded an additional $ 60.5 million in September for expanded scope from U.S. Department of Defense ( DoD ) for advanced clinical development through licensure and commercial manufacturing ; SAB has announced four awards currently totaling more than $ 203 million since March of 2020 Dosed the first patient in Phase 3 trial in October 2021 SAB - 176 , a quadrivalent polyclonal antibody therapeutic candidate currently being evaluated in an ongoing Phase 2a challenge study for the treatment of seasonal influenza Phase 2a topline data are expected in the fourth quarter of this year Autoimmune Diseases Pipeline : SAB - 142 , a human polyclonal antibody therapeutic candidate for type 1 diabetes and organ transplantation ( induction / rejection ) currently in preclinical development - IND - enabling studies expected to begin in the first quarter of 2022