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☑ 1934 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , D.C. 20549 FORM 10 - K ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF For the fiscal year ended December 31 , 2020 TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT ☐ OF 1934 For the transition period from to Commission File Number : 000-55136 Skye Bioscience , Inc. ( Exact name of registrant as specified in its charter ) Nevada ( State or other jurisdiction of incorporation or organization ) 5910 Pacific Center Blvd. 45-0692882 ( I.R.S. Employer Identification No. ) Suite 320 , San Diego , CA ( Address of principal executive offices ) 92121 ( Zip Code ) Registrant's telephone number , including area code : ( 949 ) 480-9051 Securities registered pursuant to Section 12 ( b ) of the Act : Title of each class : None Name of each exchange on which registered : None Securities registered pursuant to Section 12 ( g ) of the Act : Common Stock , Par Value $ 0.001 ( Title of Class ) Indicate by check mark if registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . ☐ Yes No Indicate by check mark if registrant is not required to file reports pursuant to Section 13 or Section 15 ( d ) of the Act . ☐ Yes ☑No Indicate by check mark whether the registrant ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the registrant was required to file such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days . > Yes □ No Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S - T ( § 232.405 of this chapter ) during the preceding 12 months ( or for such shorter period that the registrant was required to submit such files ) . < Yes □ No Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S - K ( § 229.405 of this chapter ) is not contained herein , and will not be contained , to the best of registrant's knowledge , in definitive proxy or information statements incorporated by reference in Part III of this Form 10 - K or any amendment to this Form 10 - K . | × Indicate by check mark whether the registrant is a large accelerated filer , an accelerated filer , a non - accelerated filer , a smaller reporting company , or an emerging growth company . See the definitions of “ large accelerated filer , " " accelerated filer , " " smaller reporting company , ” and “ emerging growth company ” in Rule 12b - 2 of the Exchange Act .