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Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , D.C. 20549 FORM 10 - K ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended : December 31 , 2020 Or TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 Delaware ( State or Other Jurisdiction of Incorporation or Organization ) For the transition period from : _ to SEMLER SCIENTIFIC , INC . ( Exact name of registrant as specified in its charter ) 2340-2348 Walsh Avenue , Suite 2344 Santa Clara , CA 95051 ( Address of Principal Executive Office ) ( Zip Code ) 001-36305 ( Commission File Number ) ( 877 ) 774-4211 ( Registrant's telephone number , including area code ) Securities registered pursuant to Section 12 ( b ) of the Act : None None . Securities registered pursuant to Section 12 ( g ) of the Act : Title of each class Common Stock , $ 0.001 par value 26-1367393 ( I.R.S. Employer Identification No. ) Indicate by check mark if the registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . Yes No Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15 ( d ) of the Act . Yes No Indicate by check mark whether the registrant ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the registrant was required to file such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days . Yes > No Name of each exchange on which registered OTCQB Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S - T ( § 232.405 of this chapter ) during the preceding 12 months ( or for such shorter period that the registrant was required to submit and post such files ) . Yes No Large accelerated filer Non - accelerated filer Indicate by check mark whether the registrant is a large accelerated filer , an accelerated filer , a non - accelerated filer , a smaller reporting company , or emerging growth company . See the definitions of " large accelerated filer , " " accelerated filer , " " smaller reporting company , " and " emerging growth company " in Rule 12b - 2 of the Exchange Act . Accelerated filer Smaller reporting company Emerging growth company If an emerging growth company , indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13 ( a ) of the Exchange Act . Indicate by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness of its internal control over financial reporting under Section 404 ( b ) of the Sarbanes - Oxley Act ( 15 U.S.C. 7262 ( b ) ) by the registered public accounting firm that prepared or issued its audit report . Indicate by check mark whether the registrant is a shell company ( as defined in Rule 12b - 2 of the Act ) . Yes No The aggregate market value of the voting and non - voting stock held by non - affiliates of the registrant was approximately $ 193,177,552 as of June 30 , 2020 , the last business day of the registrant's most recently completed second fiscal quarter . The number of shares of the registrant's common stock outstanding as of February 26 , 2021 was 6,708,672 . DOCUMENTS INCORPORATED BY REFERENCE