Good morning, everyone, and welcome to Supernus Business Update conference call. At this time, all participants are on a listen-only mode. Later, we will conduct a question-and-answer session. Instructions will follow at that time. As a reminder, this conference call is being recorded. I would now like to turn the conference over to Peter Vozzo, Investor Relations Representative for Supernus Pharmaceuticals. You may begin. Thank you, Lydia. Good morning, everyone, and thank you for joining us today as we discuss the acquisition of Sage Therapeutics, which was announced earlier this morning. On the call with me today are Jack Khattar, Supernus' Chief Executive Officer, Tim Dec, Senior Vice President and Chief Financial Officer, Jonathan Rubin, Senior Vice President, Research and Development and Chief Medical Officer, and Brian Roecklein, Senior Vice President, Corporate Development. Today's call is being made available via the investor relations section of the company's website at ir.supernus.com. During the course of this call, management may make certain forward-looking statements regarding future events and the company's future performance. These forward-looking statements reflect Supernus' current perspective on existing trends and information. Any such forward-looking statements are not guarantees of future performance and involve risks or uncertainties, including those noted in the risk factor section of the company's latest SEC filings. Actual results may differ materially from those projected in these forward-looking statements. For the benefit of those of you who may be listening to this replay, this call is being held and recorded on June 16th, 2025. Since then, the company may have made additional announcements related to the topics discussed. Please reference the company's most recent press releases and current filings with the SEC. Supernus declines any obligation to update these forward-looking statements except as required by applicable securities laws. I'll now turn the call over to Jack. Thanks, Peter. Good morning, everyone, and thanks for joining us on the call to discuss the exciting transaction we announced earlier today. Throughout the presentation, we will be referring to slides that have been provided through the webcast for this call. Starting on slide four of the presentation, I would like to provide an overview of the transaction with the timing for closing and integration. Regarding the purchase price, the offer price is $8.50 per share in cash at closing, plus $3.50 per share payable according to specific milestones in contingent value right. $1 per share is the Zurzuvae's U.S. net sales, as reported by Supernus, which is 50% of the net revenue reported by Sage's partner, Biogen, reached $250 million or more by year-end 2027. Another $1 per share if Zurzuvae's U.S. net sales reach $300 million or more by year-end 2028. Another dollar per share if Zurzuvae's U.S. net sales reach $375 million or more by year-end 2030. An additional $0.50 per share at commercialization in Japan by Sage's partner, Shionogi, by June 30, 2026. The equity value of the offer is $561 million at closing, and the total potential value of the offer is up to approximately $795 million, or $12 per share. Other considerations regarding the transaction: the transaction clearly provides immediate diversification of revenue and acceleration of the top-line growth for Supernus. It is also expected to be significantly accretive to adjusted operating income on a non-GAAP basis, operating income in EPS in 2026. This transaction represents a strong fit with the existing Supernus infrastructure and is expected to yield up to $200 million in potential synergies on an annualized basis. The financing of the transaction will be through cash on the balance sheet. As far as the timing of the transaction, it is expected to close in the third quarter of 2025, and we will be working very closely with our colleagues at Sage on the transition and integration planning to ensure continued success. The Sage commercial infrastructure plays a key role in sustaining the launch momentum of Zurzuvae and expanding the reach to additional prescribers. On next slide five, looking at the strategic rationale and what this transaction provides Supernus, first, it strengthens our leading psychiatry portfolio. Currently, Supernus has a strong presence in psychiatry with Qelbree in ADHD and also is developing SPN-820 in the depression space. This transaction adds an innovative commercial product to our psychiatry portfolio with Zurzuvae in postpartum depression. Zurzuvae will be a new growth catalyst in our portfolio given the strong launch and continued momentum that it has experienced so far, and it will expand also our reach into new channels through the OB-GYN physician target audience. That could represent in the future growth opportunities from a business development perspective. Third, the transaction diversifies and increases our revenue base and cash flow, and it will provide us with a new long-term growth driver. As I mentioned earlier, we expect the transaction to be significantly accretive to 2026, adjusting operating income and earnings per share. The transaction also provides synergies because of the overlap with existing infrastructure. Meaningful synergies are expected to be up to $200 million on an annualized basis, and Supernus is very well positioned to execute alongside Sage's partner, Biogen. The transaction also strengthens our internal R&D discovery capabilities by augmenting our discovery platforms and expertise. With that, I will now turn over the call to Brian to walk you through Zurzuvae and the commercial opportunity in postpartum depression. Thank you, Jack. Next slide six. I'm going to give a brief top line on the product Zurzuvae: postpartum depression, a little epidemiology information, and then discuss the brand performance to date. On slide six, it's indicated here that Zurzuvae is the first and only oral treatment specifically indicated for the treatment of adults with PPD, and that would essentially be women. There are two clinical studies that showed a rapid and sustained improvement in depressive symptoms versus placebo. Over a 14-day course of treatment was seen as early as day three and maintained at day 45. In those two studies, SKYLARK and ROBIN studies, a statistically significant improvement in depressive symptoms versus placebo was seen at day 15 following a 14-day treatment course. Zurzuvae was also studied as adjunctive therapy as well as monotherapy in these clinical studies, allowing flexible dosing or therapeutic intervention by both providers and for patients. It's a novel mechanism and class. Zurzuvae is a neuroactive steroid GABA A receptor positive modulator with a mechanism of action thought to be related to its positive allosteric modulation of GABA A receptors. This fits very nicely with our corporate development growth strategy of developing and acquiring innovative differentiated assets. Please note the safety information below where Zurzuvae may decrease awareness and alertness, which can affect a person's ability to drive safely. The most common adverse reactions and incidents greater than or equal to 5% and greater than placebo are somnolence, dizziness, diarrhea, fatigue, nasopharyngitis, and urinary tract infection. Please see the prescribing information for box warnings and any additional safety information. On slide seven, talk a little bit about the epidemiology. Postpartum depression or PPD poses a substantial burden to patients and their families. It's estimated that about one in eight women with a recent live birth experiences symptoms of PPD, or approximately 500,000 women per year. On the right top of the slide, you see that of those 500,000, only 40% are diagnosed. Of those 40% that are diagnosed, only 60% are treated. Both Sage and Biogen have spent a lot of time and effort increasing the awareness and the diagnosis rates as well as the treatment rates, and we will continue to work with Biogen to increase all three aspects of this particular therapeutic area. PPD symptoms are one of the most common complications of pregnancy and childbirth. Perinatal depression is inconsistently diagnosed, as mentioned before, and may be an under-treated condition. Mothers with perinatal depression often face significant challenges with functioning and infant bonding. There's a significant economic burden associated with perinatal depression, and it vastly impacts patients, their families, employers, and healthcare payers. On the next slide, slide eight, talk a little bit about the successful launch of Zurzuvae. One of our key goals is to capitalize on the foundation for the fantastic launch that was initiated by Sage and Biogen. The top hand side of the slide, you see your histograms representing 50% of collaboration revenue reported by Biogen. If you look at Q1 2024 compared to Q1 2025, you see 123% year-over-year growth. From Q4 2024- Q1 2025, you see a 21% quarter-over-quarter growth. Fantastic initial launch and continued growth. The bottom left, we very clearly have mentioned a couple of times that we have a collaboration in the U.S. with Biogen. Supernus will receive 50% of the U.S. net revenues reported by Biogen, and Supernus and Biogen will share certain U.S. operating expenses. In addition to the U.S. partnership, there's ex-U.S. collaborations as well, both with Biogen and Shionogi. Shionogi has submitted an NDA in Japan for major depressive disorder back in September 2024. Biogen has also submitted several filings in the EU, U. K., and Canada. Supernus is eligible to see milestones and royalties on partner ex-U.S. net sales. The right-hand side here, we talk about the successful launch foundation. It's the first and only branded oral treatment for PPD becoming established as a first choice treatment post-delivery. There's strong awareness of Zurzuvae among OB-GYNs and psychiatrists, approximately 90% brand awareness. PPD diagnosis and treatment rates are growing, and a recent expanded sales force and promotional efforts have increased utilization of revenue in 2025. There's also an increasing number of prescribers with a 20% increase in writers in Q1 of 2025. Approximately 95% of lives are covered with a favorable or acceptable path to coverage across commercial Medicaid, with the vast majority covered in PPD with no step edits or complex prior authorizations. Patient testimonies have been positive and consistent with Zurzuvae clinical profile in postpartum depression. What's very nice to see is that the media attention and public interest has increased awareness and reduced the stigma of PPD, hopefully driving more patients to seek help and get the appropriate therapy. Last slide for me. Supernus is optimally—slide nine here—Supernus is optimally positioned to execute commercially while potentially expanding the opportunity in collaboration with Biogen. We have a track record of successful commercial execution and product integration. We'll continue to establish Zurzuvae as the first choice for women with PPD. Also continue to expand postpartum depression awareness, diagnosis, and treatment. We plan to work with Biogen to enhance commercial reach across all channels, encourage and normalize PPD patient dialogue, and continue to deliver positive patient experiences. On the right-hand side, you see a Venn diagram that captures the initial promotional efforts and focus, predominantly in OB-GYNs, where approximately 70% of the prescriptions are currently coming from, but there's an opportunity to build awareness, diagnosis, and treatment both in psychiatry and primary care as well. That's the end of my section. I'll turn it over to Jack. Thanks, Brian. Moving on to slide 10, you will see how this transaction significantly helps us in building for the long term with what will become four different growth drivers in our portfolio. On the left side of the slide, you'll see on the Parkinson's area, we will have two products: growth drivers, Apokyn and Onaco. Onaco is the new infusion device for apomorphine that we just launched in April of this year. On the right side of the slide, you'll see in the psychiatry/OB-GYN space, Zurzuvae and Qelbree. And you'll see a note of the growth between the different products across the different quarters that we're showing on the slide. Zurzuvae is a very exciting asset that we will be adding to our portfolio. It will represent a new growth opportunity for us into the future and, of course, diversify our revenue growth and the cash flows. Moving on to the next slide. Slide 11 shows you the overall picture of the transaction. First, with the commercial portfolio now will be consisting of nine marketed products, including Zurzuvae. Also at the bottom of the slide, it will show you the combined expanded pipeline providing Supernus also with opportunities for future growth through the potential partners in the collaboration here, Biogen, as Brian mentioned, through their marketing efforts in Europe, potentially Canada and other markets, and Shionogi, potentially in Japan. We will also be evaluating the preclinical pipeline that Sage has as we proceed to determine from a portfolio optimization perspective the different areas that could present themselves as potential investments in further R&D projects. In summary, this transaction positions us for significant long-term growth. It really adds another major growth drivers. We now will have four growth drivers that drive our future performance and allow us to continue to build a leading position in CNS. We are very excited also, as I mentioned, about the pipeline, the innovation in the pipeline, and what this transaction adds to our expertise on the discovery side to further give us the opportunity to have sustained innovation and growth into the future. With that, I will now turn it over for question and answer. Thank you. Please enter on. To ask the question, you will need to press * 11 on your telephone and wait for your name to be announced. Please stand by while we compile the candidate roster. Now, first question coming from the line of Andrew Tsai with Jefferies. Your line is now open. Hey, congrats on the deal. Thanks for taking my question. First question is, how exactly are you guys deriving $200 million of cost synergies, up to $200 million, from Sage? Can you describe a little bit more in detail the precise overlap you have already for you to be spending, based on our calculation, 35%-40% of what Sage was currently spending? Is it safe to assume much of their later-stage R&D programs will be paused under your supervision? Thank you. Yeah, thanks, Andrew. The synergies are going to be coming across several areas as we look at the SG&A, R&D, of course, as well. A lot of the synergies will be coming from both areas. Now, one important thing to note here, the commercial infrastructure of Sage and all the efforts behind Zurzuvae are extremely important, obviously, and will be continued investment in the future moving forward. Most of the synergies will be on the G&A side and the R&D side. Got it. What can you guys do to drive stronger sales and more awareness in the PPD market that Sage may be going to do? What areas do you think you can improve on? Thank you. This is not an issue of improving or anything like that. We believe that Sage and their partner Biogen has done a phenomenal job launching this product, and the momentum behind the product is fairly evident from the first quarter results that were reported by Biogen and Sage. This is an effort that we will be talking, discussing with Biogen, of course, after closing with our partner and working with them closely as Sage has done over the past couple of years or so. The product certainly is in its infancy as far as launch. It's only been launched about a year, year and a 1/2. Clearly, the growth potential of this product is huge, given what Brian just mentioned earlier. 500,000 women every year experience symptoms in PPD. There is nothing really that has been studied well and approved for the treatment of PPD. At the end of the day, the way we look at it is Zurzuvae actually could become the standard of care, has the potential to become the standard of care in PPD. This is a huge opportunity. As I mentioned earlier, we are building and will continue to build greatly on the great success and impeccable launch that Sage and Biogen have done so far. We will be working closely with our future partner, Biogen, on that. Great. Thank you. Congrats. Thank you. Our next question coming from the line of Stacy Ku with the Cowen. Your line is now open. Hey, good morning. Thanks so much for taking our questions. Congrats on the announcement. First, starting big picture, our best understanding is the vast majority of prescribers are OB-GYNs. Maybe talk about initial commercialization plans and where you expect to grow usage. Is psychiatry a new clinician target, or is it one that you expect to grow? That's the first question. The second is a follow-up on the cost synergies. Can you also maybe talk to the timing? It seems like it should happen quickly, given your commentary on 2026. Just help us understand what kind of OpEx increase we should be expecting in the short term to look at Sage's current spend and how quickly your synergies could occur? Third question is just maybe talk about the Biogen relationship. Thanks so much. Yeah. Regarding the first question on the split between OB-GYNs and psychiatrists and other physicians, about 80% of the prescriptions are coming from OB-GYNs, so certainly heavily weighted. You would expect that because OB-GYNs are at the front and center of this disease. They're the ones who really see these patients clearly, as you would expect that. This, as I mentioned earlier in my prepared remarks, will give us a great opportunity here to further expand our presence in OB-GYNs with further potential BD transactions and augment our presence in the OB-GYN space. As far as growth, clearly the growth is coming from both sides. Again, the majority at this point, early in the launch, is through the OB-GYN space. Now, clearly, we have a significant presence in psychiatry. That is an area which we will be looking at very, very closely as far as potential synergies here with our existing commercial footprint. Anything regarding the commercialization of Zurzuvae, we will be working very closely with our partner Biogen in making any specific decisions on the future of the product. As far as the cost synergies, again, I cannot be very specific at this point, but as I mentioned earlier, we expect the synergies to be primarily coming from the G&A area and the R&D rationalization of the R&D efforts. Sorry, I couldn't get off mute. Maybe talk about your relationship with Biogen, whether you expect any changes to current kind of collaboration. Yeah. I mean, like every other partner we have, we expect to have a great collaboration and working very closely with them in building what we believe here is a significant product. As I mentioned earlier, a significant product that could become the standard of care in PPD. Thanks so much. Thank you. Now, next question coming from the line of Annabelle Samimy with Stifel, Your line is open. Hi. Thanks for taking my question and congratulations on this development. Just following on Stacy's questions about how you plan on leveraging your relationship, your psychiatry infrastructure, given that the majority of prescriptions are sitting at the OB-GYN office, do you have any plans to establish any kind of referral networks into your psychiatry relationships? It seems like that's where the big expansion opportunity could be. Just following on that, are there any kind of limitations that you have in terms of increasing your investment to be able to bring these patients or sort of create a referral network to be able to leverage that psychiatry infrastructure? Yeah. Natural question, of course. I mean, again, given our presence in psychiatry, that would be an area which you would expect us to look very closely at as far as potentially further leveraging our infrastructure and provide additional opportunity to grow the brand. Obviously, as I mentioned earlier, the initial launch momentum and everything so far has been through OB-GYNs, as evident by the fact that 80% of the prescriptions are coming by OB-GYNs. That does not mean in the future there is not the potential there to expand further in the psychiatry space as we continue and we will expect to continue to improve awareness, education, and so forth among prescribers, among the physician audience, whether they were in the OB-GYN space or in the psychiatry space. As the product gains more and more awareness and use in the marketplace, we expect the footprint of prescribers to continue to grow in both market segments, the OB-GYN space as well as psychiatrists. Certainly, we have great expectations here. We strongly believe in the potential of this product. We have no limitations that I can think of right now. Certainly, we will be working very, very closely with our partner after the closing, our partner Biogen, in discussing the plans for future as we continue to launch the product. The product is still in its very, very early launch mode at this point. This is a huge, huge opportunity driven by OB-GYNs and, yes, potentially even further, deeper into the psychiatry space. Okay. If I could just follow on that, this obviously takes you into a whole new area, as you mentioned, into the OB-GYN office. I mean, you are a CNS-focused company. When you talk about using the OB-GYN office as a potential new area of investment, are we talking about moving away from CNS into more women's health type of opportunities, or am I reading that incorrectly? As you probably recall, previous calls, when we're always asked about business development, I've mentioned this several times that we are CNS-focused. We continue to look for corporate development opportunities, external growth opportunities in CNS, whether it's psychiatry or neurology, as well as I've expressed it several times that we're also very open to get into new areas where we can be very effective and build a very good presence. Interestingly, this is a product that actually crosses over between psychiatry and OB-GYN. You couldn't ask for a better addition to our portfolio should we decide to go outside CNS. We are going into outside CNS, but with a CNS product. This is an incredible opportunity for us here to continue to be focused on CNS, as well as open up a whole new platform for ourselves through OB-GYN. Certainly, with this transaction, we are very committed and will be committed to continue to invest in the OB-GYN space and potentially look for other product opportunities that we can augment our presence with. This is not a signal of we're walking away from anything specific, but rather a signal that we will continue to invest in both CNS and OB-GYN. Okay. Thank you. Thank you. As a reminder, to ask a question, please press * 11. Our next question coming from the line of Kristen Kluska with Cantor Fitzgerald, Your line is now open. Hi, this is Rick Miller, on for Kristen. Thanks for taking our questions and congrats on the deal. To just start out at a high level, what was it about the postpartum depression market and the asset itself that convinced you that now is the right time to invest in PPD? Yeah. As we mentioned earlier, there hasn't been anything over the years, which is mind-boggling, that has been developed for women who suffer from PPD. This is an area where there is really no true medication that has been studied well or approved by the FDA for use. Women need something that is clearly well-designed, developed, and studied, and approved for that specific indication. That on its own clearly represents something that is very novel in the marketplace, again, that could become the standard of care in this space. Currently, or before Zurzuvae, I should say, people were using antidepressants, SSRIs, a lot of products that may or may not be actually adequate or even suitable for postpartum depression. That clearly differentiates Zurzuvae in the marketplace. Also, as evident by the results so far, as I mentioned earlier, the excellent launch by Sage and Biogen and the response that the companies have been receiving from early adopters, women who have used the product, everything has been very consistent with the clinical profile of the product. A lot of the riders, most of the riders are repeat riders. That also tells you something clearly. Actually, about 70%, if I'm not mistaken, of the prescriptions are for women. It's the first treatment for postpartum depression. It's not even a second-line treatment. It's a first-line treatment. Again, that's why I keep saying this could potentially become a standard of care for PPD. All these collectively have convinced us that this is a product with significant growth potential and really can be a dynamite addition for our portfolio for the future growth of the company. Thank you. And one more question from us. You mentioned that most patients aren't requiring complex prior auth. Can you help us understand what the process currently looks like and how rapidly patients are moving from this symptom state to diagnosis to eventually getting on Zurzuvae? Yeah. As Brian mentioned earlier, about 90%-95% coverage in the commercial Medicaid space, which is mainly how the payer split is, which is truly incredible for a product in this space, especially in the overall depression space. That, again, speaks to the uniqueness of the product, the differentiation of the product itself versus generic medications that people have been using historically. Actually, on an average, it's about three days, maybe one week, that it takes from the time a prescription is issued until a product is shipped to the patient. Again, that is actually a very, very good turnaround from the time a prescription is issued to the time a product is shipped. That speaks to the process, of course, of processing, whether there is a PA or specifically there are no step edits. In a lot of the cases, the patient is really getting the product fairly quickly. Overall, very, very good situation and seems to be actually helping with patients getting the product as soon as possible. That is a very good turnaround from the time a prescription is issued until the time a patient is getting the shipment. That is really pretty good timing. Okay. Thank you. Thank you. As we get no further questions from the Q&A queue at this time, I would now like to turn the conference call back over to Mr. Khattar for any closing remarks. Thank you. In summary, today's announcement represents a major step forward for us in accelerating its mid to long-term growth in revenues and cash flow and in further diversifying our revenue base with a very unique and highly differentiated product as Zurzuvae. The transaction strengthens our product portfolio with a fourth growth driver and has the potential of becoming a standard of care with the Zurzuvae addition to our portfolio. Thanks for joining us on the call. We look forward to updating you on our next call. This concludes today's conference call. Thank you for your participation, and you may now disconnect.