Good morning, everyone. My name is Rand Sutherland, Chief Executive Officer of Upstream Bio, and it is my pleasure to welcome you to today's annual meeting. I will serve as chair of the meeting, which is being held in accordance with both our bylaws and Delaware law. Our 2026 annual meeting is now called to order. I'm joined at our virtual meeting by members of our board of directors and our management team, including Allison Ambrose, the company's General Counsel and Secretary, who will be recording the meeting minutes. Also with us today is Frank Loftus of PricewaterhouseCoopers, the company's independent registered public accounting firm. Let's proceed to the formal business of the meeting, which is described in our notice and proxy statement, a copy of which was made available on or about April 16th, 2026 to all of our stockholders of record as of the close of business on April 13th, 2026, the record date for this meeting. Rules of conduct for this meeting are available in the Meeting Materials section of the virtual meeting platform in the lower right-hand corner of the screen. Please be aware that only stockholders of record as of the close of business on April 13th, 2026, or their duly appointed proxies who have logged in using their 16-digit control number will be able to vote and ask questions during the meeting. If you have any questions relating to the specific agenda items on which stockholders are entitled to vote, please submit them now so that they will be in the queue to be answered. The board of directors has appointed James Rate, an independent inspector of elections, designated by Broadridge Financial Solutions, to act as inspector of elections for this annual meeting. The inspector of elections has signed the oath of his office, which will be filed with the minutes of this meeting. He will tabulate the voting results. The inspector of elections has informed us that more than a majority of the shares of common stock entitled to vote at this meeting are represented. I therefore declare that a quorum is present. It is now 9:02 A.M. on June 9th, 2026. The polls for each matter to be voted on at this meeting are now open. If you are eligible to vote and have not yet submitted your proxy, or if you want to change your vote, you may do so by clicking on the link provided through the virtual meeting platform at any time during this meeting prior to the polls closing. Let's now proceed to the formal business of the meeting. Our first item of business is the election of directors. At this meeting, we will be voting on two nominees for Class II directors, each to serve for a term of three years and until his respective successor has been duly elected and qualified, or until his earlier death, resignation, or removal. All is set forth in the proxy statement. In accordance with the bylaws, the board of directors has nominated Edd Fleming and Liam Ratcliffe to be elected to serve as Class II directors. The company's bylaws require that a stockholder provide advance notice to the company of a stockholder's intent to nominate persons as directors. No such notice was received. Accordingly, I declare the nominations for directors closed. The board of directors unanimously recommends that stockholders vote in favor of each of the nominees. The second item of business is the ratification of the appointment of PricewaterhouseCoopers LLP as the company's independent registered public accounting firm for the fiscal year ending December 31st, 2026. The audit committee of the board of directors, which is comprised entirely of independent directors, appointed PricewaterhouseCoopers as the company's independent registered public accounting firm to audit the company's financial statements for the fiscal year ending December 31st, 2026. The board of directors approved this selection and has asked the stockholders to ratify it. If the stockholders do not ratify the selection of PricewaterhouseCoopers, the board of directors and the audit committee will reconsider the appointment. We will now pause to address any questions concerning the matters to be voted upon. As we have not received any questions related to the matters to be considered at this meeting, we will now proceed with the final voting. If you have not yet voted and desire to do so, please vote now through the virtual meeting platform. It is now 9:04 A.M. on June 9th, 2026. The polls for each matter to be voted on at this meeting are now closed. No additional ballots, proxies, or votes, no changes or revocations will be accepted. The inspector of elections has provided the preliminary results of the vote on each matter. With regard to Proposal 1, a plurality of the votes cast have been voted in favor of the election of the persons nominated. With regard to Proposal 2, a majority of the votes properly cast for and against the proposal has been voted in favor of the ratification of PricewaterhouseCoopers LLP as the company's independent registered public accounting firm for the fiscal year ending December 31st, 2026. I declare that all the proposals presented at the meeting have been ratified or approved by the stockholders. The final results of voting, including any ballots and proxies recorded during this meeting, will be set forth in the report of this inspector of elections, will be included in the minutes of the meeting, and will also be included in a Form 8-K to be filed with the SEC. There being no other matters for consideration, I hereby adjourn this meeting. Thank you for attending.