Make a career out of trying to cover might be you guys, not because I would do it well, but there's just so much fascinating, cool stuff to go to. And it always seems to originate with a certain degree of passion in terms of solving big problems that probably a lot of people said, you know, not sure that that can be done. And a lot of big organizations going back decades couldn't get done very well. So tell us about you, how long you've been at United, why you're still here, and what your, you know, aspirations are. Sure, sure. So before I do that, just let me state that today I may make some forward-looking statements. Very well trained. If anyone wants to learn more about our risk and uncertainties, they should check out our SEC filings. About me, I've been at United Therapeutics for 15 years, and I've been in the industry for 33 in operations. Started at Genentech back when it was still Genentech, and really has, you know, grown a passion for pharmaceutical manufacturing and serving the patient community. You know, as far as what, you know, keeps me going is really, you know, Martine, her leadership and her own passion for serving the community and solving big problems really excites me, and I know it excites all the employees at United Therapeutics. So the organ manufacturing and the opportunity to participate in that has been amazing. And it's really science that, you know, 20 years ago was really science fiction at that point in time. So the fact that it's becoming a reality and then we're about to embark into a clinical study, which I'm sure we'll talk about later, is really amazing. Yeah, no, and a title called Technical Operations feels very, I don't know, Clark Kent. I'm sure there's a lot more under the cover of what technical operations means. So what's the average day like for you at United Therapeutics these days? Well, it's a long day, and it's usually an exciting day. That's what shareholders want to hear. My responsibilities reside in overseeing all of our manufacturing, quality assurance, and regulatory affairs. So there's a lot going on at the company. I get to participate in all of it to varying degrees, and I don't, you know, I don't have very many boring days, put it that way. Okay, no, that's excellent. I suppose, Dewey, you and I know that a lot of investors have signed on to get the latest in terms of the United Therapeutics story and the stock. So let's sate those desires because there's a couple of things. We don't have to tell the whole story, but you and I have known each other for a very long time. Tyvaso is very much, you know, the center of gravity here, just tremendous transformation for the stock, for the story when the INCREASE study read out here. And then we live in the land of worry in the investment community about, you know, why won't it go to the sky and all these different things. Certainly, the PH-ILD opportunity and thinking about the DPI. Let's address some of the basics here before transitioning, but I do intentionally, just my forward-looking statement is I do want to capitalize on your presence here and talk about some of the organ business here. But let's just touch so that I don't get hate mail. Tyvaso, Dewey, tell us about, you know, what we should be understanding. And you have conversations with investors, post the calls afterwards all the time here. You know, ILD growth, transition from DPI to nebulizer. What's the right way to be thinking about, you know, direction of how those are going? Yeah, so we had made comments on the first quarter earnings call that Tyvaso is now in a period of inflection upward following the PH-ILD launch. And I think some of that is due to more acceptance of the fact that there's a treatment for PH-ILD out there. And it's also the recent expansion of our sales force where we now have field reps, MSLs, which are medical science liaisons, nurse specialists, and reimbursement specialists in the field dedicated to PH-ILD. We expanded the force to reach these community practices that aren't necessarily center-based. And we're starting to see roots of that even in the first quarter after this expansion. And so this is something that we've been looking forward to in terms of really reinforcing Tyvaso's place in the PH-ILD landscape. And on top of that, the DPI provides a lot of convenience for patients. You can use it on the go. I think we've lost our inhaler device like 4 times today because it's so small. Pat will pull it out if you haven't lost it already. Oh, I lost it already. We want to give patients choice. So providing the utmost choice for patients in inhaled therapy is important to us, whether it's the nebulizer or whether it's the DPI. We give them that choice. We're also seeing inroads in PH-ILD where the nebulizer can be used to titrate patients up to an efficacious dose in one breath increments versus the DPI, which is three breaths. You can titrate the patient up and then transition over to DPI. So we are seeing elements of that in patient prescribing. Since you brought the show on talent, you're the technical ops guy. Let's do a little bit of a detour here because there is a little bit of a debate, some of it intentionally, you know, scripted in terms of how Dewey is trying to help educate the street about your devices, your DPI, and then also other modalities for delivering from a competitor that is attempting to do so and is navigating some of the legal domains here. But what is it that you would say is the way to think about the profile and why this is the right device for patients? Well, I think as I look at the data from really a scientific standpoint, it's not so much how the device operates. It's what is the result of the device delivery, which is really measured in the PK. And this is a very efficient device. The potential competition product requires a lot more API to get to the same PK values that we show with this device. So the efficiencies are very good with this device. We anticipated when we developed this product that it would be more efficient than our nebulizer, which it is by about 10%. So this product requires about 10% less API than the nebulizer to get to the same dose, whereas the competitive product requires quite a bit more. So that tells you a little bit about device performance. And that's what we really focus on is it's not so much the design. It's what is the outcome of that design. It's intentional that we're trying to improve the patient experience. The reality is that the less API you need to get an effective dose is better. That's what we believe. That's what we strive for. People use these devices. People are of various different competencies and also circumstances. I think there's another message as well in terms of the elegance of the device and how the consistency of the patient experience is a valid differentiator as well. Oh, absolutely. And I want to acknowledge the contributions that our partner made with this device, MannKind. MannKind, right. Who spent 10 years really developing this device for the diabetes insulin market. We've been able to leverage that. That design experience is invaluable. You can see just as I hold this up, this weighs about an ounce. You literally cannot feel it when you're carrying it. It's easy to load and use. You pop the cartridge in, close it, and inhale. It's very quick. Whereas the nebulizer, it's a process to use it. There's some benefits to the nebulizer, which is why it still exists. You know, it really is beneficial that we can offer two means to inhale treprostinil to the medical community and to the patients. It gives them options, and they can choose the most preferred one, the one that works best for them. And so patients are voting with their feet what they like, what they can do, et cetera. What do you think is the right study statement mix of nebulizer versus DPI, Dewey? So we now see roughly a 60/40 split revenue-wise for Tyvaso DPI versus nebulized Tyvaso. We probably will continue to trend upward a bit, but there will always be a base use of nebulizer, either for the titration benefits for PH-ILD patients. Some patients prefer the nebulizer over the DPI for various reasons and also reimbursement reasons. Some patients may prefer the nebulizer. So there will always be some base use. And I think early on we had said a 70/30 split is a good way of looking at it. I'm not ready to commit to that, but I think it will trend upward from the 60/40 that it is now. Just to be clear, and you glossed over it a little bit, the economic reasons in terms of when the invoice comes, there's a difference in terms of the payer backdrop for the nebulizer versus the DPI. Can you just be explicit to educate everyone? Yeah, so the nebulizer is covered under the Part B as in boy medical benefit, while the DPI device is very easy to remember because it's Part D as in DPI, pharmacy benefit. And so there have been recent changes in the way Part D is reimbursed for some patients that have been a favorable tailwind for us so far this year with the implementation of provisions of the IRA. And there's some extra provisions that will continue in 2025 that will continue to benefit us there. Got it. And every commercial company we've been asking about this Medicare Part D redesign implications. The first answer is always drug by drug, depends upon the portfolio, characterize what the net net net net net is for United Therapeutics in terms of if we look at the revenue forecasts or at least the 2024 experience, what is the net net impact? Yeah, so we mentioned on the first quarter earnings call that our prior rate of free drug that was given out because of Part D provisions in 4Q was about in the high teens percent. We're seeing it in the low double -digits percent after Q1. And so that's a pretty substantial portion of patients that have transitioned to paid drug for us. And we expect that to continue down over time. And the other Part B drugs that we have in our portfolio, it's generally mid single digit percent that are on the patient assistance program. So we could see a continued trend down through this year as patients come to us throughout the year. They're generally on some other high-cost drug, and they probably have met their copay obligations for 2024. So they come to us as a paid patient with zero copay to them, so much like our commercial programs. And then in 2025, because the provisions of the IRA allow for an even lower copay throughout the year, and you can spread it through 12 months as opposed to paying it upfront, you'll probably have more patients that will be able to afford that out of pocket early on in the year. So we could see an additional step down then. Topical has also been making these things, manufacturing facilities, et cetera, capacity. Anything to know about where you are relative to the anticipated demand for these devices? It sounds like we've built up some capacity. Any things that still are going to make progress for, or have we addressed that? We've been working hard with MannKind on a capacity expansion at their site up in Danbury, Connecticut. We're now at the point capable of supporting 25,000 patients annually with their capacity. In addition to that, about a year ago, we kicked off a capital program to build a facility on our RTP campus. That facility is being designed to support 50,000 patients. In addition to that, there's other things we can do with the process to further expand that. Ultimately, our plans are to be able to manufacture product for up to 75,000 patients. If we get to 75, I think we've got a good problem on our hands. We'll have other capacity expansion discussions at that point. Got it. And part of the bridge to getting to that 75 number is thinking about additional indications. This brings to mind IPF and the TETON trial. Dewey, just a quick update. I think we previously had you comment that you expect to complete trial enrollment by year-end 2024. Are we still on track? Yeah, so on the last screening call, I think we mentioned that the TETON 1 study, which is in the US and Canada, was I believe 75% enrolled and increasing. For TETON 2, I believe we said it was 80% enrolled. I'm happy to say today that TETON 2 has been closed for screening. So we have the patients in the pipeline to be able to fully enroll that study in the next month or two. And so that obviously meets our goal of enrollment by the end of the year. We would expect TETON 1 obviously to be enrolled by the end of the year as well. This, as a 52-week study, would position us for data in 2025. Cool. Very exciting. And then finally, in topics that are not organ manufacturing related, PAH and the introduction of Merck's WINREVAIR. We had Rob Davis, Dean Li, talk about how the initial commercialization has gone. They're very pleased. There's a backdrop of enthusiasm, which we're familiar with. You've been asked this question in terms of being basically the franchise position with PAH therapies across different modalities. What kind of commentary can you share with what your commercial and clinical people are seeing out in the field during this first couple of months? Yeah, yeah I mean, it's early on, so we haven't seen really the impact yet. But it's our expectation, and we've discussed this before, that it'll complement treprostinil and prostacyclin therapies. So we're expecting to see that. A survey done by Wells Fargo was published today, and the physicians are backing that up and validating that belief that it's complementary. So I think it's all good for the PAH community. Thinking back 20 years ago when there was really very few options for them, the fact that they have now 16 or 17 different products to treat, it's an amazing outcome. Okay, awesome. Let's turn to the next chapter, very much a part of the United Therapeutics story going forward. Actually, I've always thought of this as a little bit of a Google moonshot initiative kind of for the company. This is going back because I've been paying attention to you guys for so many years. But without a doubt, with all sorts of silly little metrics when I looked at the deck that you guys showed up in San Francisco with, very clearly, this is what you guys are putting a great deal of emphasis. You're revealing more here. It might have been like 40% of the slides or something. So let's talk organ manufacturing. I think most people on the street have to do work. And as they begin to dive in, it's fascinating. You know, 25-30 years ago, I was a clinician sitting there running the igloo cooler into the operating room, doing organ transplants. There's a fundamental dilemma here. There's shortages. There's kind of a construct here that is looking for a solution. Enter Martine, United Therapeutics, kind of the right crew to go in there and again do badass difficult things. So investors can be fascinated, but probably won't give you necessarily credit. They like tangible things like clinical data and revenue models. You've begun to tease. You've thrown out some big round numbers, et cetera. But come on, man, help us out. Give us some step stools, which is what we need to become a little bit smarter about this. You know, I think I laid sort of the introduction. I think about the structure. There's organ assist and organ manufacturing, dealer's choice. Which one should we do first? Again, with a mindset of I'm hungry for potentially more advanced programs first to talk and spend more time there. Where do you want to go? You pick. Okay. Well, first of all, we're ready to talk about all of it. Okay. First of all, you called it a moonshot. It's not a moonshot because it's possible. Therefore, it's an earthshot to us. Yeah, no, I said I contemplated it years back. And we're going back. The first time we heard about this, you know, over half a decade ago, it was again this whole notion, and it's not meant to be pejorative, but more sort of the standpoint of experimenting with what might be possible. And the fact that it is such a front and center presence in your corporate presentation suggests that it is possible. And just bringing to bear my own history as formerly as a clinician, you know, in the prior century, it was this question of, you know, what could make sense here? So okay, let's go with organ assist, right? Lung perfusion, liver assist product. This seems a little bit more the natural glide path because all of a sudden we're sort of saying what is available and how can we make what's available better, right? Is that fair? Yep. Tell me what's the right way. Educate the investors about organ assist. Well, so there's two things there. One is the lung perfusion service that's a commercial service that we offer today. We have two facilities in Silver Spring and in Florida that do that work. What they do is they take donated lungs that were deemed unacceptable for transplant. They run a process on them that allows them to become acceptable. So those lungs are handled and put through that facility. That's been going on for some time now. Give us a sense. How many lungs are harvested in an annual basis in the U.S. and what percentage of them are unacceptable? There's all sorts of reasons. People weren't riding motorcycles without helmets, and they aspirate, and they bring it into the lungs. That's not usable. You know, as far as lung transplants go, I think the data I saw from 2023 is around 2,400 transplants. So, a very small amount. Out of a total denominator of what? Because I think this is a magnificent unmet need. Yeah, I mean, it's pretty, you know, challenging for people that are looking for a lung transplant. Many of them, you know, don't even go on the list because the supply is so few. But with this service we offer today, and this is after running for a few years, we've been able to recover close to 500 lungs that would have been discarded, and those have been transplanted. So that's made a nice dent. But it's not enough. In addition to that, we're working on a process to improve the perfusion process. We recently completed a clinical study involving that. And we're going to file a PMA later this year to be able to implement that new process. So a lot of. Just to go backwards. So we're talking about the product actually has an acronym, I believe, and I did a little bit of homework. EVLP, right? Ex Vivo outside the body Lung Perfusion. We're really talking building blocks here. We're trying to be clever elementary school students here. The strategy was to establish our presence in the transplant community, which we've done that. The promise is these lungs, are we going to, you know, you're going to give longer durability. You're going to have higher yields. What's the pitch? I think it's going to just result in an improved lung outcome for patients. So it won't necessarily change the percentage of accessible lungs? Well, it could. You know, I think we'll have to wait to see what the long-term impact is. But the fact is that there's, you know, 400+ people walking around today that may not have lived because we were able to recover these lungs. That's a tremendous impact. So that's one piece of the puzzle. Of course, our acquisition of Miromatrix late last year, and this is on the liver side. They've got an IND approved for their bioengineered liver. And they'll be kicking off a clinical study there. Now, that's an external liver that's really meant to be a bridge. So that's exciting progress there as well. So we're seeing immediate returns on that investment. So there's a lot happening. Sure. Okay. I'm trying to organize the thoughts because I think it's a big morass and a mosaic and acronyms here. So to keep it so that people come away with something that they can grab hold of. Organ assist, two products, EVLP, Ex Vivo Lung Perfusion. We've talked what that is about. That is to enhance sort of the viability of harvested lung tissue. You talked about 400 patients. That was over what period of time? Have we accrued 400 patients? Yeah, that's a long. One year, five years? No, it's been five years at least. Okay. Got it. So we have some sense for sort of like the crescendo of the efforts here. Regulatory, you know, clinical data. Are we ever going to have clinical data that sort of demonstrates how good is EVLP? Well, as I said, we just completed a clinical study. When will we learn it? When will you show us the data? At an upcoming medical conference. Yeah. Okay. During the next 12 months? To be determined. Okay. Again, I have to ask these questions, right? And then milestones then, once you have the data, then you go to the regulators, et cetera. So what is the potential timeline for this? So that we have an FDA? PMA filed before the end of the year. PMA. Okay. Good to know. Yeah. premarket approval. Approval expected in 2025. At the same time, Chris, we do have an approved service called XPS that we use that is from Ex Vivo Perfusion. This data that we're talking about in the PMA is for what we call CLES or CLES, Centralized Lung Evaluation System. It's very similar to the XPS, but it uses different consumable components. We are on the market with an approved product. Obviously, it's not our approval, but we do provide the service as an approved service to transplant centers. Okay. It makes sense that organ assist is just further along in terms of ultimately being a product that's FDA approved and becomes a revenue generator as opposed to organ manufacturing. The science is still further behind or no? No, it's revenue-generating for us now. The XPS services are. It's not going to be the core revenue driver for United Therapeutics. Of course not. Yeah, it's a core service. Again, it's like contemplating what stage you're at. You actually have prospect for revenues coming from this over the next couple of months. So it's very good to start sharpening their principles and thinking about this type of opportunity, which I think they are not, which is part of the benefit, hopefully, of this discussion here. So key risks to organ assist? From an enterprise standpoint, like what could make this not happen? So I think with the liver program, so our miroliverELAP, miroliverELAP, it will be the first bioengineered organ to enter a clinical study. Period. And that is for acute liver failure. So patients that have a liver toxicity event and need either have hours or days to live or desperately need a liver transplant can go on this circuit that it perfuses. I'm sorry, it doesn't perfuse, but it uses a bioengineered organ, so a pig liver with allogeneic human cells in it to perform basic liver functions to allow the recipient's native liver to recover from this acute toxicity event. So the idea is to increase the supply of transplantable livers by reducing the need for transplant in these patients that can be served with an external product for up to 48 hours. Okay. Conceptually, it's almost like a metaphor for dialysis or ex-dialysis. Ex-dialysis of the liver, yeah. Got it. Okay. Very cool. Very logical. Organ manufacturing. Okay. Here's where things get a little bit utopian, right? Multiple approaches are being taken. Artificial organs, natural or synthetic materials. Also, and this is just broadly in terms of those people are thinking of like, let's make organs, right? Regenerative medicine-based approaches, you know, for which the underpinning is kind of like, you know, let's reduce the chance of having the complications of rejection risk because the immune system is really useful but can be annoying. 3D organ printing, right? 3D tissue printing is, you know, you can start with all sorts of stuff like the cartilage around the ear. That's really cute. But like we're really talking about complex biological processes here. So the level of sophistication is getting exponential. And then xenotransplantation. And this is where all of a sudden I think you get a lot of clicks. The topic does certainly. New York Times, just the media is curious and fascinated by some of these dimensions here. So walk us through each of these in terms of organ manufacturing and what United Therapeutics cares the most about. Well, I think we care about all of it. Let's talk about xeno first because I think that's what people hear most about today because it's close to becoming reality. So the 10-gene xeno kidney is really what's going to lead the charge here. We've just finished the non-human primate studies that FDA requested of us prior to being able to file an IND. So the plan right now is we'll meet with FDA probably sometime end of Q3, early Q4 of this year, propose a clinical study to them, get their feedback, and file an IND in early 2025 and have the first human transplant sometime thereafter, maybe mid-2025. Now, in relation to that, when we talk about manufacturing, we've also talked about on our quarterly calls the status of our clinical DPF, which is where the pigs are housed and where the lungs or the organs are harvested. That facility is now up and running. There is a population of genetically modified pigs in that facility. What's happening now is we're expanding that herd and preparing it to be ready to support the clinical study. This is now no longer a concept. This is becoming reality. It's been a long journey, but it's right around the corner. We're very excited about that. Great. Why pigs and for which organs? So the pigs are interesting. You know, their organs are very similar to ours. And they're easy to breed. They're easy to genetically modify. And all these things played a role in selecting a pig for this purpose. So they're really a good, say, factory for these organs. And a lot of research has been done on that, driven by Revivicor, who we acquired in 2011. And we've continued to develop that science. Following the kidney will be the 10-gene heart, which many of you have heard about the compassionate use transplants that happened earlier this last year and in the prior year. And then, of course, the most recent, the 1-gene thymo kidney will also come out of that as well. So we have a couple areas we're pursuing with xeno. And all that's coming to fruition now. In relation to the other technologies you mentioned, we have a regenerative medicine program where we're taking porcine lungs, decellularizing them, and then depositing allogeneic cells on those lungs or on those scaffolds to grow a functional lung. Very challenging to do that, but a lot of progress has been made by the teams working on that. So that's another option as we pursue the lung transplant, which, you know, as we go back to the founding of United Therapeutics, Martine's goal was to cure PAH, and that remains a goal. The only cure is a lung transplant. But what's holding these people back, of course, is the availability of lungs to transplant. So again, that's a priority for us. And then, of course, you mentioned the 3D printing. That might be really the best technology in the end, although that's equally as complicated where we print a lung scaffold and we're able to cellularize it with either allogeneic or hopefully in the future autologous cells, which will really eliminate the need for immunosuppression, which is one of the challenges we face with some of the other technologies with xeno, of course, immunosuppression will always be present. So a lot of, you know, we call them shots on goal. And so we're pursuing a lot of avenues to try to solve really the organ shortage crisis that exists. Within 3D printing, the reason why you think that may ultimately be the best is because of the potential for juxtaposing that in the context of autologously sourced from the person themselves, reducing very materially the risk of having that biology screw things up. Exactly. Exactly. Okay. Then the reason why this is even possible now, and you kind of went through it. And again, you're assuming that we all understand what you do. And so I'm probably being a little bit of a junior high school teacher here, but it is advances, to my understanding, in the gene editing that has enabled that, or am I wrong? Well, certainly with xeno, CRISPR, the use of CRISPR certainly accelerated what was happening with the gene modifications. I would tell you the knowledge of managing the different cells that are used to populate these scaffolds. What's been learned over the last few years is that that can be a successful endgame. Miromatrix and IVIVA is their knowledge of being able to manipulate these cells to do certain things. Extremely complicated science. And it's years of investment, years of knowledge that's gained. So it's very complementary towards our business. Okay. Regulatory is inevitably a gatekeeper. 2022, there was an advisory committee meeting on xenotransplantation. What's the most important thing that you think an investor should understand as a takeaway from that that's somehow one of the rules for the road for how you're conducting your development? Yeah. I mean, I think the big thing is FDA is very supportive of these efforts. They understand the need. They see the shortage. People are unfortunately dying on the waiting list. They know there needs to be a solution here. Not only, you know, people on the waiting list, but the people that can't even get on the waiting list. If we talk about kidney, there's close to 100,000 people waiting for a kidney transplant. There's another 400,000 on dialysis to get on the list. So that's pretty dismal. We can do better. I think with the efforts that we're making, we're going to start to see a solution here with one of these technologies. We love numbers. We live for numbers. You guys started to introduce market opportunity. The fundamental building blocks of the most simple equation is N times price. You started to give some market numbers. Prevent me from going the wrong direction. What are the inputs to these market projections that you gave? And just so I can understand that. So the inputs, I mean, the primary driver would be pricing, obviously. That's driven by the alternatives for these patients. So dialysis is $150,000 a year. Patients are on dialysis 8-10 years. What's the cost to the system in terms of dollars, but also patient productivity, patient satisfaction, patient ability to not be tied to a dialysis center? Then on the corollary to that would be, are these curative? Then gene therapies are curative. And they're also very expensive. So that represents the two kind of the wide range that we gave for pricing. I think as we get to a clinical program and we determine the right patient for xenotransplant, because we can look at the alternatives for these patients. Just very simplistically, think about the glorious margins that pharmaceutical companies can have. I do not understand what the margins could look like for, let's say, a standalone business in the organ manufacturing business. You said the word PMA, which is sort of like a device, you know, modality path from a regulatory standpoint. How do margins compare? And how should we think about margin progression for United? Yeah. I mean, we're expecting the margins to be very similar to what we see for drugs. Okay. Yeah. The ultimate margin will be determined by the end pricing. So, I mean, that margin you gave, the 300-900,000, that the margin varies greatly depending on where we end on that. Okay. People want to be smart and learn more often. It's that much more compelling for public equity investors to be able to pay attention to somebody else's program. We love Coke versus Pepsi, et cetera. But I think this is a scenario where the advancements are progress for anybody lifts all boats and the tide comes in. Any other entities, hopefully public, so that they can disclose, but if not, who are the leaders in this field that you bump into in the meetings who are doing good work? Primarily, it's eGenesis. eGenesis had a patient at Massachusetts General who received a 69-gene edit kidney. Their ultimate construct is very similar to ours. Just the 59 of the 69 edits deal with an endogenous retrovirus that they have eliminated from the genome. We have done it through breeding. We just had natural selection do our gene editing for us. Then 9 of the 10 edits that remain are identical between the two constructs. It's very similar. We don't look at them as a competitor, and they don't look at us as a competitor. We're peers. We're trying to advance this to help patients. At the end of the day, it's not a net zero game because there's not enough supply. There won't be enough supply for the massive demand that's out there for kidneys. Okay. No, that makes sense. Then we'll close this out with a little Wall Street stuff because your last quarterly call intentionally had Martine read scripted commentary that talked about capital allocation priorities and shareholder returns, et cetera, including the share repurchase. Where are we with that? And I was intrigued by that, you know, attention to capital allocation priorities as sort of like, this is the message this. We got in that question on the accelerated share repurchase. When's the next one? Yeah. So this accelerated share repurchase, obviously, we received the shares, but or 80% of the shares, but our agent is still purchasing shares. We'll do that through the end of September. Then that program will expire. I think we've had a very, very good reception for it. My team loves positive reinforcement. I'm still employed, which is wonderful. But it is, it's something where capital allocation is always part of the equation for us. I think with a successful execution of it, it continues to be something we think about. But our ultimate goal is to help patients. The way we can help patients is through organs and investing in ourselves and looking at technologies in rare disease that can help patients. That's why investing in ourselves and business development come ahead of return of capital. But as capital is available, it's something we consider on a regular basis. Okay. No, that totally makes sense. Sounds really adult. So good for you guys. Patrick, thank you so much for telling us a little bit more about the story. Look forward to more conversations. Dewey, always great to see you. Thank you. Thanks so much.