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( Mark One ) ☑ ◎ UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , D.C. 20549 FORM 10 - K ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31 , 2020 OR TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM ΤΟ Commission File Number : 001-39979 VOR BIOPHARMA INC . ( Exact name of registrant as specified in its charter ) Delaware ( State or other jurisdiction of incorporation or organization ) 100 Cambridgepark Drive , Suite 400 Cambridge , Massachusetts ( Address of principal executive offices ) 81-1591163 ( I.R.S. Employer Identification No. ) 02140 ( Zip Code ) Registrant's telephone number , including area code : ( 617 ) 655-6580 Securities registered pursuant to Section 12 ( b ) of the Act : Title of each class Common Stock , $ 0.0001 par value per share Securities registered pursuant to Section 12 ( g ) of the Act : None Trading Symbol ( s ) VOR Name of each exchange on which registered Nasdaq Global Select Market Indicate by check mark if the registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act . Yes No Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15 ( d ) of the Act . Yes No Indicate by check mark whether the registrant : ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the registrant was required to file such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days . Yes □ No Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S - T ( $ 232.405 of this chapter ) during the preceding 12 months ( or for such shorter period that the registrant was required to submit such files ) . Yes No □ Indicate by check mark whether the registrant is a large accelerated filer , an accelerated filer , a non - accelerated filer , smaller reporting company , or an emerging growth company . See the definitions of " large accelerated filer , " " accelerated filer , " " smaller reporting company , " and " emerging growth company " in Rule 12b - 2 of the Exchange Act . Large accelerated filer Non - accelerated filer ㅁ ☑ Accelerated filer Smaller reporting company Emerging growth company ☐ If an emerging growth company , indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13 ( a ) of the Exchange Act . Indicate by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness of its internal control over financial reporting under Section 404 ( b ) of the Sarbanes - Oxley Act ( 15 U.S.C. 7262 ( b ) ) by the registered public accounting firm that prepared or issued its audit report . Indicate by check mark whether the registrant is a shell company ( as defined in Rule 12b - 2 of the Exchange Act ) . Yes No As of June 30 , 2020 , the last day of the registrant's most recently completed second fiscal quarter , there was no public market for the registrant's common stock , $ 0.0001 par value per share ( " Common Stock " ) . The registrant's Common Stock began trading on the Nasdaq Global Select Market on February 5 , 2021. As of March 12 , 2021 , the aggregate market value of the Common Stock held by non - affiliates of the registrant was approximately $ 517,549,577 , based on the closing price of the registrant's Common Stock on March 12 , 2021. This calculation does not reflect a determination that certain persons are affiliates of the registrant for any other purpose . The number of shares of registrant's Common Stock outstanding as of March 12 , 2021 was 37,127,865 .