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Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , DC 20549 Form 10 - K ☑ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 . For the fiscal year ended December 31 , 2020 ☐ TRANSITION REPORTS PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 . For the transition period from to Nevada Commission File Number : 001-37937 XENETIC BIOSCIENCES , INC . ( Exact name of registrant as specified in its charter ) ( State or other jurisdiction of incorporation or organization ) 40 Speen Street , Suite 102 Framingham , MA 01701 45-2952962 ( IRS Employer Identification No. ) ( Address of principal executive offices and zip code ) 781-778-7720 ( Registrant's telephone number , including area code ) Securities registered pursuant to Section 12 ( b ) of the Act : Trading Symbol ( s ) XBIO XBIOW Name of each exchange on which registered Securities registered pursuant to Section 12 ( g ) of the Act : The NASDAQ Capital Market The NASDAQ Capital Market Title of each class Common Stock , $ 0.001 par value per share Purchase Warrants None Indicate by check mark if the registrant is a well - known seasoned issuer , as defined in Rule 405 of the Securities Act : Yes No Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15 ( d ) of the Act : Yes □ No Indicate by check mark whether the registrant ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the registrant was required to file such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days : Yes > No ☐ Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S - T ( § 232.405 of this chapter ) during the preceding 12 months ( or for such shorter period that the registrant was required to submit such files ) : Yes No □ Indicate by check mark whether the registrant is a large accelerated filer , an accelerated filer , a non - accelerated filer , a smaller reporting company or an emerging growth company . See the definitions of “ large accelerated filer , ” “ accelerated filer ” “ smaller reporting company " and " emerging growth company ” in Rule 12b - 2 of the Exchange Act . ( Check one ) : Large accelerated filer Accelerated filer Non - accelerated filer ☐ ☑ Smaller reporting company Emerging growth company 冈 ☐ ☐ ☐ If an emerging growth company , indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13 ( a ) of the Exchange Act . □ Indicate by check mark whether the registrant has filed a report on and attestation to its management's assessment of the effectiveness of its internal control over financial reporting under Section 404 ( b ) of the Sarbanes - Oxley Act by the registered public accounting firm that prepared or issued its audit report . □ Indicate by check mark whether the registrant is a shell company ( as defined in Exchange Act Rule 12b - 2 ) : Yes¨ No x