Afternoon. Thank you for joining Zevra's second quarter 2026 financial results and corporate update conference call. Today's call is being recorded and will be available via the investor relations section of the company's website later today. The host for today's call is Nichol Ochsner, Zevra's Vice President of Investor Relations and Corporate Communications. Thank you. Welcome to those who are joining us. Today, we will provide an overview of our recent accomplishments, followed by a review of our second quarter 2026 financial results. I encourage you to read our financial results news release, which was distributed this afternoon and is available in the investor section of our website. Before we begin the call, please note that certain information shared today will include forward-looking statements. Actual results may differ materially from those stated or implied by any forward-looking statements due to risks and uncertainties associated with Zevra's business. Forward-looking statements are not promises or guarantees. They are inherently subject to risks, uncertainties, and other important factors that may lead to actual results differing materially from the projections made and should be evaluated together with the risk factors section in our most recent quarterly report on Form 10-Q, our annual report on Form 10-K, and our other filings with the SEC. This call will also reference certain non-GAAP financial measures, including adjusted net income and adjusted net income per share. Quantitative reconciliation of these measures to the most directly comparable GAAP measures, as well as information regarding the usefulness of these measures to management and investors, are included in the earnings press release issued today, which is available on our website. I am pleased to welcome Zevra's management team members participating in today's call. Neil McFarlane, Zevra's President and Chief Executive Officer, Josh Schafer, our Chief Commercial Officer, and Justin Renz, our Chief Financial Officer. Now it's my pleasure to hand the call over to Neil. Thank you, Nichol, and welcome to everybody joining our quarterly call this afternoon. At Zevra, our mission is to redefine what is possible in bringing life-changing therapies to people living with rare disease. Our strategy to unlock long-term value through focused execution has translated into measurable results across our business. For the second quarter, our net revenue was $39.7 million, a 53% increase year-over-year. This was driven by $30.2 million in net U.S. revenue for MIPLYFFA. Our commercial progress reflects continued momentum in reaching patients and successfully establishing MIPLYFFA in combination with miglustat as a foundational treatment for Niemann-Pick disease type C, or NPC, in the U.S. As of June 30th, we had received a total of 184 prescription enrollment forms, 14 of which were received in the second quarter, bringing the total in the first six months of the year to 23. We have strengthened our intellectual property position for MIPLYFFA with an Orange Book listing through 2041. We published long-term data from our U.S. early access program and the findings from our pediatric sub-study, further demonstrating the efficacy and safety of MIPLYFFA. We requested a re-examination of our arimoclomol Marketing Authorization Application, or MAA, by the Committee for Medicinal Products for Human Use, or CHMP, in the European Union. We continue to build a strong financial foundation with more than $260 million in cash equivalents, and investments. Our strategic focus is reflected in the thoughtful portfolio decisions we are making while maintaining an unwavering sense of urgency on behalf of patients. Most recently, we announced that following our oral explanation, the CHMP issued a negative opinion regarding arimoclomol MAA. Subsequently, we are advancing the re-examination process, which will provide the opportunity to address the specific grounds cited in the CHMP opinion and have our comprehensive evidence package reviewed by a new rapporteur and co-rapporteur. This process typically takes 120 days from the submission of a re-examination to the opinion from the CHMP, which is expected in Q4. Importantly, as we advance through the European regulatory process, our commitment to the patient and the NPC community remains steadfast. We will maintain access to arimoclomol for eligible patients through our global expanded access program, or EAP, which is comprised of compassionate use and reimbursed named patient programs that have enrolled 132 patients, with 10 added in the second quarter. As previously guided, we expect reimbursements beyond the French EAP to be highly variable in the first few years until the patient base has stabilized. Ordering patterns for patients outside of Europe remain unpredictable, with some territories ordering a full year supply and others ordering on a monthly or quarterly basis. Simultaneously, we are evaluating opportunities to expand access to MIPLYFFA through the global EAP in response to strong interest from additional countries. This reflects our commitment to helping eligible patients outside the U.S. access treatment while building meaningful partnerships across the rare disease community. Additionally, we strengthened our U.S. intellectual property position for MIPLYFFA with an Orange Book listing that provides protection through 2041. We are still awaiting the determination for the separately requested patent term extension through the U.S. Patent Office, which if granted, would fall within the Orange Book coverage period. Together, our IP portfolio provides a strong foundation for the long-term commercial opportunity for MIPLYFFA. We continue to invest in expanding and strengthening our protection beyond our current portfolio. At the same time, we are advancing celiprolol, a selective adrenoreceptor modulator that induces vascular dilation and smooth muscle relaxation for the treatment of Vascular Ehlers-Danlos Syndrome or vEDS. vEDS is a rare genetic connective tissue disorder caused by changes in the COL3A1 gene, leading to fragile walls in blood vessels and hollow organs, which can cause arterial rupture or dissection, among other complications. Celiprolol has been shown to reduce the mechanical stress on these tissues. In our ongoing Phase III DISCOVER trial, we've enrolled a total of 66 patients, including four who were enrolled in the second quarter. As an event-driven study, 28 events are required to trigger the interim analysis, and we have three confirmed events thus far. We are focused on accelerating this program by implementing strategies to drive enrollment, including expanding our network of genetic testing centers and exploring options to advance our clinical development by engaging with the FDA. Following a Type C meeting in Q1, we remain on track to reengage with the FDA in the second half of this year. In summary, our priorities remain clear: delivering innovation for people living with rare disease, creating sustainable value for our stakeholders, and fulfilling our commitment to the patients, healthcare providers, and communities we serve. I'll now turn the call over to Josh to share more details regarding MIPLYFFA's commercial performance. Josh? Thank you, Neil, and good afternoon. NPC is an ultra-rare genetic disease that causes significant neurological impairment and places a substantial burden on patients and families. Clinical manifestations can include dysfunction of ambulation, fine motor skills, swallowing, and speech. The disease and its symptoms vary significantly across patients, reflecting its complexity and severity. Earlier this year, the NPC clinical practice treatment guidelines were updated to further characterize the disease and reflect new advances in treatment since its last publication in 2018, including the addition of MIPLYFFA. Importantly, the guidelines recommend considering combination therapy for all patients with confirmed NPC. As a reminder, MIPLYFFA is differentiated as the only FDA-approved treatment for NPC with established efficacy and safety indicated for use in combination with miglustat. The randomized controlled pivotal study demonstrated the combination halted NPC disease progression at 12 months as assessed by the rescored four-domain NPC Clinical Severity Scale, a validated measurement of NPC progression. The onset of benefit was rapid, with clinical effects sustained over the long term. MIPLYFFA's clinical data, combined with a growing awareness across the NPC community, continues to support its adoption. As Neil mentioned, we have received 184 prescription enrollment forms since launch through June 30th. The 14 we received in the second quarter included patients from Puerto Rico, reflecting our reach into U.S. territories. As we have noted previously, an enrollment form is a prescription submitted to our specialty pharmacy, which then begins the benefits investigation process to determine reimbursement eligibility. Notably, patients initiating treatment are being enrolled from centers of excellence and community practices with representation across both newly diagnosed and previously diagnosed patients, as well as adult and pediatric populations. This distribution supports our confidence in the estimated prevalence of 900 patients living with NPC in the U.S., of whom 300 to 350 are diagnosed. Our commercial strategy is centered on three key priorities: accelerating diagnosis and treatment, driving demand, and facilitating access to MIPLYFFA. The progress we are seeing reflects the growing impact of initiatives being implemented across each of these areas. Our disease awareness campaign, Learn NPC, Read Between the Signs, is driving the identification of patients based on symptoms and has led to new patient enrollments for MIPLYFFA. Our genetic testing collaborations and our custom AI-driven targeting model are helping to support the identification and diagnosis of patients with NPC, allowing for earlier intervention. We also launched our Expert Connect program, which has enabled healthcare professionals who are less familiar with NPC to consult one-on-one with clinical experts to further strengthen knowledge and confidence. Additionally, we expanded and enhanced our digital engagement through the launch of NPC Knowledge Hub, providing resources to help patients and caregivers navigate the treatment journey. From a market access standpoint, payer coverage remained at 69% of covered lives, consistent with our expectations. We continue to share presentations with payers on the recent update to the NPC Clinical Practice Guidelines, as well as the growing body of newly published clinical data on MIPLYFFA. Additionally, we convene payer advisory boards with key decision-makers to inform our strategy on how best to support prescribers and patients as they navigate the reimbursement landscape. We maintain strong relationships with the rare disease community and assembled steering committees to gather expert insights and help shape NPC disease awareness. In the second quarter, we participated in national and regional congresses, including the American Academy of Neurology, the Society for Inherited Metabolic Disorders, and the Annual Children's Neuroscience Symposium, to enhance scientific visibility and educate clinicians and researchers. This strong engagement has continued into the third quarter with our participation at the National Niemann-Pick Disease Foundation Conference, where the importance and interest in a combination strategy for NPC treatment was highlighted prominently. Before turning the call over to Justin to review the financials, we want to reiterate our deep gratitude for the opportunity to make a meaningful impact in the lives of patients and their loved ones. We remain committed to being a trusted partner in the community by providing compassionate, patient-centered support. Justin? Thank you, Josh. Underpinning our achievements is a strong financial foundation and a robust cash position, which provide the flexibility to invest in commercial execution, advance our pipeline, and pursue future growth opportunities while maintaining financial discipline. In addition to the financial details included in today's call, we encourage you to refer to our quarterly report on Form 10-Q for more detailed information, which we intend to file later today. In the second quarter of 2026, we generated total net revenue of $39.7 million, which was an increase of $13.8 million or 53% compared to $25.9 million in Q2 2025. As a reminder, we recognize U.S. commercial revenue when MIPLYFFA shipments are received by the specialty pharmacy. Of note, channel inventory has returned to target levels as compared to Q1 when it fell below the low end of our range. The second quarter 2026 total net revenue is comprised of $30.2 million from MIPLYFFA net sales in the U.S., $0.2 million from OLPRUVA, $9.0 million in net reimbursements, and $0.3 million in pass-through royalty revenue from Corium. Revenue from MIPLYFFA in the U.S. grew 23% compared to the first quarter of this year and 40% compared to the second quarter of last year. During the second quarter of 2026, our operating expenses were $21.0 million, which was a decrease of $3.2 million compared to the same quarter a year ago. R&D expense was $4.5 million for Q2 2026, which was an increase of $1.1 million compared to Q2 2025, primarily to ongoing arimoclomol efforts. SG&A expense was $16.6 million for Q2 2026, which was a decrease of $4.2 million compared to Q2 2025, primarily due to a decrease in professional fees and third-party spending, partially offset by an increase in personnel-related costs. We allocated $4.0 million for our Q2 2026 income tax provision. Net income for the second quarter of 2026 was $8.8 million or $0.14 per basic and diluted share compared to net income of $74.7 million or $1.24 per basic and $1.21 per diluted share for the same quarter of a year ago. This quarter, we incurred a mark-to-market fair value non-cash charge of $6.4 million related to our outstanding common stock warrants. Excluding this adjustment that impacts period comparison, net income for Q2 2026 would've been $15.2 million or $0.25 per share. In Q2 2025, we would've had an adjusted net loss of $2.4 million or $0.04 per share by excluding 1x transactions and other adjustments that contributed a net positive of $77.1 million to Q2 2025's results. As of June 30, 2026, total cash equivalents, and investments were $260.2 million, which was an increase of approximately $23.4 million compared to March 31, 2026. In summary, we remain well-positioned with the financial capacity to execute on our strategic priorities independent of the capital markets. Now I'll turn the call back to Neil for his closing remarks. Neil? Thanks, Justin. Our strong second quarter performance demonstrates the strength of our strategy, disciplined execution, and continued momentum across the business. We remain steadfast in our commitment to putting patients first, a principle that is reflected in our approach to growing our U.S. commercial business, expanding our global presence, and fueling our portfolio to deliver long-term shareholder value. With that, operator, please open the line for questions. At this time, if you wish to ask a question, please press star one on your telephone keypad. You may remove yourself from the queue by pressing star two. We will take our first question from Kristen Kluska with Cantor Fitzgerald. Your line is now open. Hi, everyone. Thanks so much for taking the questions here. I had a couple this afternoon. First, you're sitting on a very robust balance sheet and have a continuing line of sight into more revenues as the MIPLYFFA business grows. Curious how you're leveraging this cash and ways you're looking to potentially explore using that. Second, wanted to talk about the EMA. You mentioned there's a new rapporteur here. Can you tell us a little bit about how that process works when there's really a new team here looking? Is there anything that you can do differently? We have seen some recent reversals, specifically in the rare disease space, curious about your thoughts there. Thank you so much. Yeah. Thank you, Kristen. Maybe I'll start with your second question. Then I'll pivot over to Justin to help talk a little bit about the strong financial foundation we've got. You are correct. In our re-examination process, we will have the opportunity to bring in a new rapporteur and co-rapporteur to further interpret the evidence that we have submitted so far. I can't actually comment on what that process will look like because I have to be thoughtful on the level of details we provide. Our confidence is grounded in the totality of the evidence and the clear unmet patient need. As you saw, we continued in our global EAP to add an additional 10 patients up to 132 patients. Those are primarily patients that are in Europe. I think that as we continue to move forward with our re-examination process, we're looking forward to bringing new expert voices into the procedural discussions and allowing for the comprehensive evidence package to shine. On that note, I'll ask Justin to talk a little bit more about our strong financial foundation and what we're doing moving forward. Thank you, Neil, and thank you, Kristen. As you noted, we ended Q2 with $260.2 million in cash equivalents and investments, that really provides us meaningful flexibility. Our priorities are unchanged as we execute against our strategic plan. Namely, we're driving MIPLYFFA growth, pursue global opportunities for MIPLYFFA, continue to advance celiprolol, again, evaluate, of course, aligned external opportunities. We're going to maintain that disciplined capital allocation strategy we've always talked of. We're going to be prudent in our investments and really focus on value-creating opportunities when we can find them. Thanks very much. We will take our next question from Sumant Kulkarni with Canaccord Genuity. Your line is open. Good afternoon. Thanks for taking our question. This one is about the EMA process. What exactly could you do to strengthen your, I guess, the request for re-examination? Is there anything new you can file in terms of the real-world data that you've generated? Or I guess the best way I could ask that is what is going to be new in this request versus what was denied in the prior documents that you sent in? Thank you. Thanks, Sumant. I think it's a really important question. The opinion that the CHMP provided reflects their assessment on the submitted evidence under this European regulatory framework that they have. Under the re-examination process, we'll have the opportunity to focus specifically to address the specific grounds that have been cited for the refusal. We believe strongly that the comprehensive evidence package, we've got an open label extension study that goes out four years. Actually, just this week, the expanded access program data that has been published has gone out for four years. The pediatric sub-study has been published now, along with a very comprehensive safety database. This robust and comprehensive package that we've resubmitted as part of this application, we're now going to go into the further interpretation of the evidence that are specific to the questions that they or the specific grounds that were cited for the refusal and bring it to light. That comes with new expert voices into the procedural discussion that will allow us to continue to educate the CHMP on this, again, I've said it a few times, but robust and comprehensive evidence package. Thanks. We'll take our next question from Eddie Hickman with Guggenheim Securities. Please go ahead. Hey, good afternoon. Appreciate you taking the questions and congrats on all the progress so far. Just two from me. On the U.S. side, can you just give us maybe some directional color on which of the segments you're seeing a rebound in? Is it sort of the GeneDx contributing to more diagnoses? Are you seeing a different level of new versus previously diagnosed, adult versus pediatric? Just help us understand sort of where the biggest opportunity remaining is. Then on the ex-U.S. side, can you sort of maybe help us bracket the sort of variable non-French EAP numbers? I know it's going to be sort of up and down maybe, but can you give some sort of bracketing for the next couple quarters on how we should model that? Appreciate it. Let me start with your second question in regards to the global EAP, and I think you're specifically asking about the reimbursed section of that. We've said previously that our French program has been very consistent. It's approximately $2.5 million net per quarter or $10 million net per year, and that program has been ongoing for a multitude of years. We have about 30 patients, plus or minus, that remain very consistent. The variability in ordering patterns that come through other named patient reimbursement programs can come in. It's one patient at a time, and it can be one patient that orders for an annual basis, one patient that orders for quarterly or a monthly supply. It's really hard for me to tell you or guide you in regard to the brackets that you're asking for, because it remains unpredictable. It's driven by the timing, the order volume, the program type, and also the geography. The only thing that I can tell you is that we remain very committed in the French EAP program, which has been consistent at about $10 million net per year, or approximately $2.5 million per quarter. Let me switch quickly to the U.S. business. Really great questions. The U.S. business, we're learning more about every day. We are seeing an equal mix between children and adults. As you know, this has been primarily a child disease for many years and kind of characterizes that. Now we're seeing quite a bit of adult patients. Those learnings are coming through. We don't have a single tactic that is working to uncover the number of patients we have. Remember, we're at 184 enrollment forms now with 14 in the quarter. This is really an integrated strategy, and I'll ask Josh to talk more about some of the things he's seen on the ground, but an integrated strategy versus a single tactic that is continuing to drive this and kind of unlocking the TAM that we think is between the 350 and 900. Josh? Yeah, thanks. Eddie, thanks for the question. As Neil mentioned, I wouldn't attribute the enrollments to any one tactic. In fact, we have a really well-integrated commercial strategy that's focused on accelerating diagnosis and treatment. We're seeing that really take place with the 23 enrollments that we've seen in the first half of this year. Those enrollments are coming with a mix of newly diagnosed patients as well as previously diagnosed patients. It's a mix of patients in centers of excellence as well as now we're able to reach out into the community and find patients who are in community practices. We're seeing patients who are young as well as adult patients. We're really pleased with the diversity and the distribution of enrollments that we're seeing, most notably because it really gives us confidence in the overall addressable market that we've been talking about, which is, we believe, somewhere between 350 and 900 patients. Appreciate it. Thank you. We will take our next question from Jason Butler with Citizens. Please go ahead. Hi. Thanks. Taking the question. Just wondering if you could give us some kind of perspective on the age distribution of newly diagnosed patients. Secondly, when you look at the tools that you're using, like the AI targeting and the Expert Connect program, are you seeing any growth in the number of prescribers over the last couple of quarters? Thank you. In terms of the age distribution of newly diagnosed patients, we are seeing patients who are coming in who are both under the age of 18 as well as some who are over the age of 18. Just within this first half, we have some very specific instances. There was a newly diagnosed child who's about two years old. Symptoms had just been presented, and the parents had her tested and confirmed with NPC. On the other hand, we have a patient who is in his mid-20s and has been misdiagnosed with epilepsy for five or six years and was finally tested and confirmed to have NPC. We're really seeing a diversity of instances and age groups reinforcing the heterogeneity of the disease. This is largely driven by the tactics that we've put in place, the AI targeting, our disease awareness campaign. All of these things are really helping to drive enrollments and, again, giving us confidence that there are more patients out there yet to be diagnosed. Yeah, Jason, just to put a little bit of a finer point on this, we've said that the age distribution between adults and kids is about 50/50 in what we see today. Of these 184 enrollment forms, you should think of that as half adults and half children. When it comes to the newly diagnosed patients, it's really difficult for us to be able to say and provide that level of guidance. For us, you should consider to say this is not just a childhood disease, as we've been thinking about this for many, many decades. These adult patients that are coming in today have got delayed diagnosis. They've got complex disease histories, and we're starting to unlock that. The 50/50 ratio remains of our total population. Great. Thank you. Once again, as a reminder, it is star one on your telephone keypad to ask a question. We will move next to Brandon Folkes with H.C. Wainwright. Your line is open. Hi, thanks very much, Chris, congrats on another good quarter. Neil, how do you feel about enrollment forms today, halfway through 2026 when we think about the full year compared to the enrollment forms you generated in 2025? It does look like things are trending up on an enrollment basis, do you have better visibility into enrollment trends today? Are you starting to get more comfortable with sort of a quarterly level of enrollment forms you expect going forward? Thanks, Brandon. Yes, you asked a question in regards to 2025. We had 52 enrollments for the year, halfway through this year, we're at about 23 enrollments. I think what gives me a lot of confidence is really around the opportunity to unlock newly diagnosed patients. We started seeing that around this time last year. Then in Q3, we saw more newly diagnosed patients, Q4, newly diagnosed patients. These efforts that Josh just mentioned previously around our bespoke AI model that's getting the EMR data along with the claims data together and helping our reps get to places where they can educate physicians that we believe have NPC patients. It's really driving both newly diagnosed as well as the previously diagnosed patients. I'm pleased with where we are through the year, but I'm even more confident about the TAM being somewhere between that 350 and 900, because we're seeing these newly diagnosed patients earlier in the launch process than we would've expected today. I'm hopeful that with continued investment on our side and others in the area in NPC, we'll continue to drive that forward. Thanks very much. Maybe just one more from me. I heard your earlier commentary on celiprolol, but any additional color you can provide coming out of that meeting, that 1Q meeting, and sort of the continued dialogue with the FDA? Did you come out of the meeting more confident in going ahead? What gives you confidence in terms of sort of moving that program forward coming out of that meeting? Just any color would be helpful. Thank you. Well, I would coin the meeting as informative. We went in to try and find ways to accelerate the clinical development program, and the questions we asked were responded to with opportunities for us to go out and do some homework. We kind of have several approaches that we're working on here. It's a parallel track, right? One is that we want to try and find ways to accelerate the clinical development through regulatory pathways, and the other is really around us and the ability to drive enrollment so we can get to the events and get to this interim analysis. As you saw last quarter, we had two confirmed events. We have three confirmed events now in Q2. We're up to 66 patients enrolled of 150 patients in the study. We'd like to be able to find ways to put our foot on the gas, and that's what our second half plans are going to be discussing with the FDA. Great. Thanks very much. We will take our next question from Lachlan Hanbury-Brown with William Blair. Your line is open. Hey, guys. Thanks for the question. Maybe the first, Neil, going back to sort of some of the prior questions, just wondering what gives you confidence that you can be successful in the re-examination? I understand your point about confidence in the overall package, but sort of confidence in maybe being able to get the rapporteurs over the line or beyond the hurdles that they've seen in this initial review because I don't typically associate EMA with being totally flexible. Then maybe a second question. Just wondering if the IP win for MIPLYFFA in the U.S. changes how you think about your ability or maybe appetite to invest in the MIPLYFFA franchise in the U.S. Let me start with your first question. I'm going to be thoughtful in the level of detail I provide, but our confidence is fully grounded in the totality of the evidence and the unmet need, right? We mentioned, again, 132 patients in our global EAP. The majority of those patients are patients that are in the European Union. I think that that's an important perspective. We continue to see the demand from patients. When it comes to the CHMP and their assessment, this process that we're working through and the stage that we're in around the re-examination process is really around now focusing on that further interpretation of the evidence that we've provided around the open label extension, the EAP, and the pediatric sub-studies. It starts with our pivotal study, right? It's primarily centered on the analysis of the pivotal study as the foundation of this application. We've got a positive, clinically meaningful and statistically significant clinical study. That's what gives us the first part of confidence. The rest of it is around the comprehensive evidence package. I can't give you a probability, but what I can tell you is that we're bolstering our clinical trial with multi-years of safety database with no new safety concerns. We believe strongly that the benefit risk is in favor of MIPLYFFA for patients in the E.U. The second question that you had was in regard to, I'm going to take that as life cycle management and IP. Yes, we're very happy with the longer duration of intellectual property protection today. And that does give us a lens towards looking at how we can further invest the capital Justin was talking about earlier today into the U.S. business, but also into the European and global expansion along with the celiprolol program. I kind of leave it at that at this point in the game. I don't want to say that we have a specific action that we'll take with the current extension, but we are looking forward to maximize the value of MIPLYFFA over the long haul. Thanks. We will take our next question from Kambiz Yazdi with BTIG. Your line is open. Hi, team. Congratulations on the quarter. Just a couple for me. On the reexamination, how are you thinking about the role of a SAG meeting and KOL testimony potentially in the process? Also maybe on your strong cash position, can you speak about your philosophy on share buybacks? Thank you. I'll take the first one, and I'll ask Justin to comment on our capital allocation plans. The answer to that question is we did resubmit for a reexamination, and we have requested a SAG meeting. That's part of bringing new expert voices into the procedural discussions, and we will take advantage of that. Justin? Yeah, thank you. Again, reiterating what we said earlier, we're in growth mode. Our priorities remain unchanged against our strategic plan right now, and that's driving MIPLYFFA growth, pursuing global opportunities, advancing celiprolol, and then again, as we just discussed, prudently at least exploring the opportunities that we might be able to invest in perhaps arimoclomol and other indications. We're going to be very much open-minded to things. We have a board, and we discuss these topics, but right now that is not part of our current capital allocation strategy. Thank you so much. We will take a follow-up question from Sumant Kulkarni with Canaccord Genuity. Please go ahead. Thanks for the follow-up. Is there anything you can share about what your latest competitive intelligence tells you about the remainder of the diagnosed and treated patients in the U.S. that are not yet on MIPLYFFA, especially in terms of them being on the other approved product like IntraBio's [FENIOSU]? Yeah. I recall this question. It's important. We believe they're complementary mechanisms of action. I think the treatment guidelines reinforce what we've been saying for many years now, that when you have a heterogeneous disease that has multi-symptomatology and just devastating progression, it's important to have as many complementary mechanisms as possible that you can utilize. I'll ask Josh to talk a little bit more about what we see in the marketplace. What we have been seeing is the guidelines along with our current real-world evidence that patients and physicians want options, and we're seeing combination therapy being not just a recognized approach, but a more common than not approach. Yeah. As Neil mentioned, as we talked about previously, Sumant, the market is really moving towards a combination therapy because the treatments that are available are very complementary to one another. This was reinforced in the treatment guidelines that came out earlier this year. Also important in those guidelines, it was recognized that MIPLYFFA was a disease-modifying treatment and is the only treatment that's FDA indicated in combination use with miglustat. As the market moves towards combination therapy, I think it really supports MIPLYFFA's ongoing use as foundational therapy. To your question about other products out there, we don't really see this as an either/or market. Many patients, certainly we know that many MIPLYFFA patients are receiving miglustat and perhaps other treatments. And so we look at this really as an opportunity to continue to grow our share of those diagnosed patients and more importantly, the undiagnosed patients. The activities that we're doing now, we're seeing new enrollments coming in on a regular basis for newly diagnosed patients, all of which gives us real confidence that the overall market size is what we think it is of 350 to 900 patients. Thanks. Thank you. We will move next to Jonathan Aschoff with Roth Capital Partners. Your line is open. Thank you. Solid quarter, guys. Just two things. Can you tell us anything about patient attrition, any commercial patients who are no longer taking the drug, and maybe a percentage there? How did the end of Q2 inventory compare to the end of one-two? Jonathan, I'll ask Josh to talk a little bit about the refill rate persistency and what we see in the market today. I'll flop it over to Justin to talk a little bit about the ending inventory. Yeah. With regards to attrition, first of all, as we noted, we've got about 69% of covered lives. We are very confident in the access that we're able to provide for patients, either through direct formulary for those 69% of covered lives or through some sort of medical exception pathway. We're seeing that most of the patients who are enrolled to receive MIPLYFFA do indeed receive MIPLYFFA. Our refill rates and compliance rates or persistence rates are really quite high. The patients that we do lose, unfortunately, it's really a reflection more of the severity of the disease. It is an oftentimes fatal disease, and patients will progress to the point of dying. The patients who we have lost and are no longer taking MIPLYFFA, the vast majority of those are patients who have unfortunately passed away. Jonathan, just to put a finer edge on that, we had discussed that patients that get on MIPLYFFA seem to stay on MIPLYFFA. Our EAP data was very supportive of that effort. The rates that we saw in terms of the patients who, as Josh mentioned, unfortunately passed away, those rates were really super small, and we're continuing to see those similar kinds of rates in our long-term data so far. Now, we're almost two years in. At the end of this year, we should be able to start seeing some more persistency, maybe we'll be able to provide that metric later on. Justin, you want to talk a little bit about inventory? In general, we have a channel inventory target that we work with our specialty pharmacy partner on, and our channel inventory fell below our targeted range at the end of Q1. It was truly because of shipping timing and the dynamics around that. For Q2, it was essentially back to the normal target level that we aspire to. I believe you'll see a normalization going forward of this level. Okay. Just a wee bit higher. Back to normal is what you're saying. Correct. Thank you very much, guys. This does conclude the Q&A portion of today's call. I'd like to turn the call back over to Neil McFarlane for any closing remarks. I thank you for joining the call today, and we look forward to keeping you apprised of our future progress. Have a great evening. Thank you. This brings us to the end of today's meeting. We appreciate your time and participation. You may now disconnect.