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Table of Contents ( Mark One ) ☑ UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington , D.C. 20549 FORM 10 - Q QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31 , 2021 or TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 ( d ) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number : 001-38068 ZYMEWORKS INC . ( Exact name of registrant as specified in its charter ) British Columbia , Canada ( State or other jurisdiction of incorporation or organization ) Title of each class Suite 540-1385 West 8th Avenue Vancouver , BC V6H 3V9 ( Address of principal executive offices , including zip code ) ( 604 ) 678-1388 ( Registrant's telephone number , including area code ) N / A 98-1398788 ( I.R.S. Employer Identification Number ) ( Former name , former address and former fiscal year , if changed since last report ) Common Shares , no par value per share Securities registered pursuant to Section 12 ( b ) of the Act : Trading Symbol ( s ) ZYME Name of each exchange on which registered New York Stock Exchange Indicate by check mark whether the registrant : ( 1 ) has filed all reports required to be filed by Section 13 or 15 ( d ) of the Securities Exchange Act of 1934 during the preceding 12 months ( or for such shorter period that the registrant was required to file such reports ) , and ( 2 ) has been subject to such filing requirements for the past 90 days . Yes ☑ No □ Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S - T ( §232.405 of this chapter ) during the preceding 12 months ( or for such shorter period that the registrant was required to submit such files ) . Yes ☑ No □ Indicate by check mark whether the registrant is a large accelerated filer , an accelerated filer , a non - accelerated filer , a smaller reporting company , or an emerging growth company . See the definitions of “ large accelerated filer , ” “ accelerated filer , ” “ smaller reporting company , ” and “ emerging growth company " in Rule 12b - 2 of the Exchange Act . Large accelerated filer Non - accelerated filer × Accelerated filer Smaller reporting company П Emerging growth company ☐ If an emerging growth company , indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13 ( a ) of the Exchange Act . ☐ Indicate by check mark whether the registrant is a shell company ( as defined in Rule 12b - 2 of the Securities Exchange Act of 1934 ) . Yes □ The number of outstanding common shares of the registrant , no par value per share , as of May 3 , 2021 was 46,170,034 . No ☑